Table 2: ARL2 inhibitory activities of compounds 10-12.

     Compounds      R      R1      IC50(μM)a
     Sorbinil      0.65
     11      H      H      4.13
     12      H      OMe      nt
     13      OMe      OMe      3.19

aIC50values represent the concentration required to produce 50% enzyme inhibition. Standard error of the mean (SEM) is ≤ 10. n.t.: not tested.