Table 2: ARL2 inhibitory activities of compounds 10-12.
|
Compounds |
R |
R1
|
IC50(μM)a
|
Sorbinil
|
|
|
0.65 |
11
|
H |
H |
4.13 |
12
|
H |
OMe |
nt |
13
|
OMe |
OMe |
3.19 |
aIC50values represent the concentration required to produce 50% enzyme inhibition. Standard error of the mean (SEM) is ≤ 10. n.t.: not tested.