Table 2: MTT-based cytotoxicity activity of selected compounds at 100 µg/mL against human lung cancer cell line A549.
| Compounds |
R |
IC50 (µg/mL)
|
| 4b |
4-Cl |
75.64 |
| 4h |
3-OCH3
|
76.54 |
| 4i |
2,4-diOCH3
|
73.32 |
| 4j |
3,4-diOCH3
|
70.36 |
| 4l |
4-CH(CH3)2
|
71.07 |
| 4m |
3-Br |
76.03 |
| 4n |
3-phenoxy |
72.87 |
| paclitaxel |
-- |
47.63 |
IC50 - is half maximal inhibitory concentration- it is the half maximal (50%) inhibitory concentration (IC) of a substance (50% IC, or IC50)