| Cmpd |
R, R1, R2 &
R3 |
CC50 (µM) |
| HT29 |
PC3 |
MDA-MB-231 |
| 18 |
R1 &
R3 = H, R2 = SCH3, R = benzyl |
3.56±1.25 |
18.86±9.71 |
4.06±1.97 |
| 19 |
R1 &
R3 = H, R2 = SCH3, R = furan-2-yl |
33.25±3.43 |
39.79±6.81 |
41.16±7.60 |
| 20 |
R1 &
R3 = H, R2 = SCH3, R = >
|
3.64±0.21 |
4.81±0.99 |
7.24±0.56 |
| 21 |
R1 &
R3 = H, R2 = SCH3, R = aminomethyl |
5.49±0.21 |
7.27±0.31 |
7.30±0.62 |
| 22 |
R1 &
R3 = H, R2 = SCH3, R = 
|
5.98±0.24 |
6.03±0.41 |
7.43±0.87 |
| 23 |
R1 &
R3 = H, R2 = SCH3, R = 
|
4.39±0.29 |
6.21±0.49 |
6.70±0.71 |
| 24 |
R1 &
R3 = H, R2 = SCH3, R = 
|
4.23±0.16 |
5.16±0.50 |
6.81±0.63 |
| 25 |
R1 &
R3 = H, R2 = SCH3, R = 
|
3.15±0.17 |
6.66±0.42 |
4.35±0.19 |
| 26 |
R1, R2 &
R3 = OCH3, R = benzyl |
<0.098±0 |
0.52±0 |
<0.098±0.04 |
| 27 |
R1, R2 &
R3 = OCH3, R = furan-2-yl |
>50.00 |
>50.00 |
>50.00 |
| 28 |
R1, R2 &
R3 = OCH3, R = methyl |
6.44±1.40 |
23.26±2.61 |
5.77±1.55 |
| 29 |
R1, R2 &
R3 = OCH3, R = aminomethyl |
8.51±1.70 |
17.92±2.08 |
9.92±2.13 |
| 30 |
R1, R2 &
R3 = OCH3, R = 
|
11.05±1.35 |
26.53±6.01 |
11.94±2.27 |
| 31 |
R1, R2 &
R3 = OCH3, R = 
|
5.21±0.39 |
11.95±1.47 |
8.87±1.38 |
| 32 |
R1, R2 &
R3 = OCH3, R = 
|
4.87±0.11 |
8.11±0.41 |
7.30±0.73 |
| 33 |
R1, R2 &
R3 = OCH3, R = 
|
5.67±1.67 |
11.94±1.56 |
8.20±0.99 |