| Cmpd | R, R1, R2 & R3 | CC50 (µM) | ||
|---|---|---|---|---|
| HT29 | PC3 | MDA-MB-231 | ||
| 48 | R1 & R3 = H, R2 = SCH3, R = phenyl | >50.00 | >50.00 | >50.00 |
| 49 | R1 & R3 = H, R2 = SCH3, R = 4-pyridyl | 10.76±1.84 | 12.73±1.44 | 9.50±2.14 |
| 50 | R1 & R3 = H, R2 = SCH3, R = 4-Fluorophenyl | >50.00 | >50.00 | >50.00 |
| 51 | R1 & R3 = H, R2 = SCH3, R = 4-N,N-Dimethylaminophenyl | >50.00 | >50.00 | >50.00 |
| 52 | R1 & R3 = H, R2 = SCH3, R = 2-naphthyl | >50.00 | >50.00 | >50.00 |
| 53 | R1 & R3 = H, R2 = SCH3, R = benzyl | >50.00 | >50.00 | >50.00 |
| 54 | R1 & R3 = H, R2 = SCH3, R = furan-2-yl | >50.00 | >50.00 | 48.76±20.34 |
| 55 | R1, R2 & R3 = OCH3, R = phenyl | >50.00 | >50.00 | >50.00 |
| 56 | R1, R2 & R3 = OCH3, R = 4-pyridyl | 9.83±1.54 | 9.09±0.87 | 8.21±0.90 |
| 57 | R1, R2 & R3 = OCH3, R = 4-fluorophenyl | >50.00 | >50.00 | >50.00 |
| 58 | R1, R2 & R3 = OCH3, R = 2-naphthyl | >50.00 | >50.00 | >50.00 |
| 59 | R1, R2 & R3 = OCH3, R = 4-methoxyphenyl | >50.00 | >50.00 | >50.00 |
| 60 | R1, R2 & R3 = OCH3, R = benzyl | >50.00 | >50.00 | >50.00 |
| 61 | R1, R2 & R3 = OCH3, R = furan-2-yl | >50.00 | >50.00 | >50.00 |