Table 1: Biological evaluation of synthesized compounds against Mycobacterium tuberculosis..

Compounds M. Wt. R group UV λmax MICa Log p Docking energy
1 238.24 600 nm  0.328± 0.01 mg/ml +2.55 -8.22
2 215.254 600 nm 0.296± 0.13 mg/ml +2.22 -7.56
3 217.184 570 nm Non active +1.97 -5.44
4 188.18 b Non active +1.55 -6.03
5 204.18 b Non active +1.16 -6.44
6 218.21 600 nm 0.33± 0.03 mg/ml +1.76 -6.47
7 172.18 570 nm Non active +1.94 -5.44
8 178.21 b Non active +1.92 -4.71
9 206.63 600 nm 0.284± 0.05 mg/ml +2.5 -7.87
10 198.22 b Non active +1.83 -4.49
11 162.14 b Non active +0.55 -4.08
12 202.21 600 nm 0.278 ± 0.04 mg/ml +1.81 -7.32
Isoniazid 0.03–0.05 mg/Lc - 0.6
TLM 210.0 0.0625 mg/mld 3.00 -6.57

aData are mean ± SD values.
bno change in the maximum absorption
cLiterature reported MIC [28] d Literature reported MIC [29]