Table 1: LD50 ADME-TOX Parameters and probability of health effects of substituted 2-(1-furan-2-yl)-4-(5-phenyl-4H-1,2,4-triazol-3-yl) quinoline using ACD/ I-Lab 2.0.

Ligands Intraperitoneal Oral Intravenous Subcutaneous
7a 710(0.27) 790(0.21) 79(0.22) 50(0.45)
7b 490(0.4) 970(0.31) 40(0.37) 820(0.36)
7c 570(0.4) 820(0.28) 43(0.35) 1100(0.35)
7d 760(0.36) 650(0.21) 49(0.32) 1400(0.28)
7e 450(0.4) 1000(0.32) 40(0.36) 850(0.38)
7f 400(0.41) 880(0.29) 33(0.36) 840(0.36)
7g 420(0.39) 1100(0.31) 29(0.36) 790(0.37)
7h 430(0.4) 990(0.32) 37(0.36) 860(0.37)
7i 470(0.39) 1100(0.28) 41(0.37) 760(0.3)
7j 520(0.32) 1000(0.3) 28(0.16) 460(0.29)
7k 510(0.2) 300(0.0) 45(0.19) 19(0.36)
7l 670(0.34) 720(0.25) 24(0.29) 330(0.35)
7m 550(0.38) 1300(0.41) 39(0.35) 980(0.34)
7n 540(0.39) 1100(0.37) 35(0.34) 750(0.38)
Pyrazinamide 2000(0.83) 540(0.28) 170(0.56) 1000(0.71)
Ciprofloxacin 930(0.72) 3500(0.78) 120(0.86) 1400(0.58)
Streptomycin 310(0.76) 880(0.53) 110(0.67) 400(0.52)

Estimated LD50-mouse value in mg / kg after Intraperitoneal, Oral, Intravenous and Subcutaneous administration. The drugs with moderate effect on reliability index (>0.5). The drugs with border line effect on reliability index (>0.3, <0.5).