Table 1:
LD50 ADME-TOX Parameters and probability of health effects of substituted 2-(1-furan-2-yl)-4-(5-phenyl-4H-1,2,4-triazol-3-yl) quinoline using ACD/ I-Lab 2.0.
Ligands |
Intraperitoneal |
Oral |
Intravenous |
Subcutaneous |
7a |
710(0.27) |
790(0.21) |
79(0.22) |
50(0.45) |
7b |
490(0.4) |
970(0.31) |
40(0.37) |
820(0.36) |
7c |
570(0.4) |
820(0.28) |
43(0.35) |
1100(0.35) |
7d |
760(0.36) |
650(0.21) |
49(0.32) |
1400(0.28) |
7e |
450(0.4) |
1000(0.32) |
40(0.36) |
850(0.38) |
7f |
400(0.41) |
880(0.29) |
33(0.36) |
840(0.36) |
7g |
420(0.39) |
1100(0.31) |
29(0.36) |
790(0.37) |
7h |
430(0.4) |
990(0.32) |
37(0.36) |
860(0.37) |
7i |
470(0.39) |
1100(0.28) |
41(0.37) |
760(0.3) |
7j |
520(0.32) |
1000(0.3) |
28(0.16) |
460(0.29) |
7k |
510(0.2) |
300(0.0) |
45(0.19) |
19(0.36) |
7l |
670(0.34) |
720(0.25) |
24(0.29) |
330(0.35) |
7m |
550(0.38) |
1300(0.41) |
39(0.35) |
980(0.34) |
7n |
540(0.39) |
1100(0.37) |
35(0.34) |
750(0.38) |
Pyrazinamide |
2000(0.83) |
540(0.28) |
170(0.56) |
1000(0.71) |
Ciprofloxacin |
930(0.72) |
3500(0.78) |
120(0.86) |
1400(0.58) |
Streptomycin |
310(0.76) |
880(0.53) |
110(0.67) |
400(0.52) |
Estimated LD50-mouse value in mg / kg after Intraperitoneal, Oral, Intravenous and Subcutaneous administration. The drugs with moderate effect on reliability index (>0.5).
The drugs with border line effect on reliability index (>0.3, <0.5).