Table 3: Cell cytotoxic effect of novel 2-(1-furan-2-yl)-4-(5-phenyl-4H-1,2,4-triazol-3-yl) quinoline and its analogues 7(a-o).
| Entry |
A375 |
MDA-MB-231 |
| IC50 (µg/mL) ±SD |
R Square |
IC50 (µg/mL) ±SD |
R square
|
| 7a |
2.9±0.249 |
0.985 |
6.2±1.09 |
0.979 |
| 7b |
4.0±0.39 |
0.972 |
9.5±1.17 |
0.97 |
| 7c |
7.8±0.41 |
0.981 |
11.3±1.11 |
0.985 |
| 7d |
9.9±0.12 |
0.946 |
45.6±0.135 |
0.989 |
| 7e |
31.6±0.64 |
0.998 |
74.1±2.21 |
0.995 |
| 7f |
6.4±0.38 |
0.977 |
13.1±1.18 |
0.950 |
| 7g |
NA |
0.921 |
173.3±2.03 |
0.967 |
| 7h |
6.1±1.30 |
0.91 |
32.3±1.55 |
0.944 |
| 7i |
29.8±0.40 |
0.928 |
88.6±1.10 |
0.912 |
| 7j |
79.3±0.89 |
0.975 |
>320 |
0.994 |
| 7k |
5.1±1.33 |
0.907 |
7.3±1.17 |
0.921 |
| 7l |
85.1±1.12 |
0.950 |
18.2±1.58 |
0.935 |
| 7m |
207.1±2.03 |
0.954 |
270.0±1.20 |
0.987 |
| 7n |
79.3±1.40 |
0.948 |
57.1±2.00 |
0.994 |
| 7o |
19.6±0.19 |
0.994 |
8.6±0.37 |
0.988 |
| Cisplatin |
1.3±0.19 |
0.994 |
5.1±0.37 |
0.988 |
A375, human metastatic melanoma cell line; MDA-MB-231, human breast cancer cell line; NA, no activity; IC50, 50% inhibitory concentration; SD, standard deviation of mean, IC50 values of compound were evaluated using GraphPad Prism 7 software. Data represent the mean ± standard deviations of three replicates (n=3). R-squared is a statistical measure of how close the data are to the fitted regression line in graph.