Table 1: Cytotoxicity in KB, HL60 and HCT116 human cancer cells (IC50, µM). [a]

Cpd. R R’ A HX 10-5M 10-6M
1 Me H CH - 0±17 0±2
4 H H CH - 0±9 0±3
6 CH - 0±3 0±2
8 CH - 0±6 0±7
9a H CH HCl 0±12 0±15
9b H CH HCl 0±2 0±9
9c H CH - 1±11 0±13
14 Me H N - 0±7 0±4
9d H CH HBr 88±5 0±17
9e H CH HBr 96±2 8±8
9f H CH HBr 98±1 57±5

[a] Experiments were performed in triplicate.