Table 2: Atrio-ventricular conduction. Extension of PQ interval in relation to time following different doses of Tinuvin 770 in dogs T1-T7 symbols represent 1, 3.3, 6.6, 10, 33.3, 66.6, and 100 mg of Tinuvin 770, respectively. Statistically significant differences are marked with bold numbers and * (P<0.05).
| Time (minutes) |
Vehicle |
T1 dose |
T2 dose |
T3 dose |
T4 dose |
T5 dose |
T6 dose |
| 0 |
0,114±,003 |
0,118±,003 |
0,114±,003 |
0,117±,004 |
0,120±,003 |
0,118±,004 |
0,124±,004 |
| 3 |
0,113±,003 |
0,120±,004 |
0,117±,004 |
0,119±,005 |
0,120±,004 |
0,125±,004* |
0,129±,006* |
| 6 |
0,114±,003 |
0,123±,003* |
0,119±,003 |
0,120±,004 |
0,122±,004 |
0,125±,004* |
0,135±,006* |
| 9 |
0,114±,003 |
0,122±,004 |
0,120±,004 |
0,119±,004 |
0,122±,004 |
0,126±,005* |
0,136±,007* |
| 12 |
0,114±,003 |
0,119±,003 |
0,119±,004 |
0,119±,004 |
0,123±,004* |
0,128±,004* |
0,135±,007* |
| 15 |
0,114±,003 |
0,118±,003 |
0,117±,004 |
0,117±,004 |
0,122±,004 |
0,125±,004* |
0,135±,008* |