Table 1: Dose-dependence of tissue and body fluid concentrations of K 117 injected intramuscularly to rats.

Sample (tissue or body fluid)	Concentration (µg/ml± SD) Determined by HPLC-UV	Tissue Concentration (ng/ml)	Tissue concentration related to the serum concentration (%)	Concentration. related to the dose of 1 µmol
Dose: 0.1 µmol
Serum	0.011±0.005	110	100.0	0.567
Brain	0.011±0.005	55	50.00	3.235
CSF	0.010±0.000	50	45.45	5.880
Eyes	0.010±0.002	50	45.45	0.990
Lung	0.055±0.004	275	250.0	2.350
Testis	0.006±0.004	30	27.27	5.450
Liver	0.043±0.005	215	195.5	39.09
Kidney	0.340±0.012	1700	1545	42.50
Inner ear	0.079±0.005	395	359.0	3.361
Dose: 0.3 µmol
Serum	0.022±0.008	220	100.0	0.378
Brain	0.015±0.004	75	34.09	1.470
CSF	0.012±0.003	60	27.27	2.352
Eyes	0.014±0.005	70	31.82	0.460
Lung	0.051±0.002	255	115.9	0.720
Testis	0.009±0.004	45	20.45	2.727
Liver	0.077±0.027	385	175.0	3.208
Kidney,	0.768±0.009	3840	1745	0.920
Inner ear	0.088±0.010	440	200.0	0.838
Dose: 1.0 µmol
Serum	0.194±0.003	1940	100.0	1.00
Brain	0.034±0.003	170	8.762	1.00
CSF	0.017±0.011	85	4.381	1.00
Eyes	0.101±0.013	505	26.03	1.00
Lung	0.234±0.006	1170	60.30	1.00
Testis	0.011±0.004	55	2.835	1.00
Liver	0.080±0.010	400	20.61	1.00
Kidney,	2.781±0.026	13905	716.7	1.00
Inner ear	0.235±0.006	1175	60.56	1.00
Dose: 3.0 µmol
Serum	0.576±0.013	5760	100.0	0.989
Brain	0.083±0.006	415	7.204	0.813
CSF	0.023±0.016	115	1.996	0.451
Eyes	0.222±0.005	1111	19.28	0.733
Lung	0.601±0.013	3005	52.17	0.856
Testis	0.093±0.009	465	8.072	2.818
Liver	0.194±0.020	970	16.84	0.808
Kidney	4.698±0.159	23490	407.8	0.563
Inner ear	0.442±0.064	2210	38.36	0.626
Dose: 10.0 µmol
Serum	2.289±0.121	22890	100.0	1.179
Brain	0.360±0.004	1800	7.863	1.058
CSF	0.075±0.004	375	1.638	0.441
Eyes	0.763±0.035	3815	16.66	0.755
Lung	1.788±0.033	8940	39.05	1.770
Testis	0.484±0.003	2420	10.57	4.400
Liver	0.153±0.002	765	3.342	0.190
Kidney	11.219±0.099	56095	245.06	0.403
Inner ear	1.246±0.047	6230	27.21	0.530