Hexacyclododecylamines with Sigma-1 Receptor Affinity and Calcium Channel Modulating Ability

Scheme 1 Reagents and conditions: (i) CH₃CN, MW, 100 °C, 150 W, 100 psi, 5 min, 94%; (ii) CH₃CN, MW, 100 °C, 150 W, 100 psi, 10 min, 92% yield from 5; (iii) EtOH, MW, 100 °C, 150 W, 150 psi, 30 min, quantitative yield; (iv) EtOH, NaBH₄, rt, 8 h; (v) acetone, 3 M HCl_(aq), 6 h, 53% [38].