Scheme 2 Synthetic routes for synthesis of derivatives 5c-7c, 8a,b,c-15a,b,c, 16c-26c. i: 100°C, 6h-120h; ii: DMA, 100°C, 24h-168h; iii: toluene, 100°C, 3.5h-96h; iv: DMF, 80°C, 2-48h (8a,b-15a,b); DMA, 100°C, 72-192h (8c-15c).