Fig. (2) Analysis of binding of CVSlead12 to the Hmg-CoA reductase site. Panel A shows the molecular interactions o CVSlead12 with the HMG-CoA reductase binding site. Panel B shows the molecular interactions of atorvastatin to the Hmg-CoA reductase site. Panel C shows a comparison table of interactions conserved between A and B. An asterisk indicates a critical bond found in the atorvastatin-HMG-CoA reductase interactions.