Table 3: Analgesic Activity of the Newly Synthesized Compounds Using the Rat Tail Withdrawal Technique

Compounda Reaction Time (sec)b
0 1 h 2 h 4 h
Control 2.82± 0.10 2.93 ± 0.10 2.95 ± 0.10 2.98 ±0.20
7a 2.92 ± 0.10 3.25 ± 0.20c (11)d 3.68± 0.20c (26) 3.99 ± 0.20c (36)
7b 2.75 ± 0.10 3.25 ± 0.20c (18) 3.62 ± 0.20c (31) 3.74 ± 0.20c (36)
7c 2.80 ± 0.10 3.95 ± 0.10 c (41) 4.02 ± 0.20 c (43) 4.25 ± 0.30c (51)
7d 3.12 ± 0.20 3.83 ± 0.20c (22) 3.92 ± 0.20c (25) 4.01 ± 0.20c (28)
7e 3.01 ± 0.30 4.10 ± 0.20 c (36) 4.25 ± 0.10c (41) 4.46 ± 0.30c (48)
7f 3.01 ±0.30 4.11 ±0.20 c (36) 4.31 ±0.20 c (43) 4.51 ±0.20 c (49)
8a 3.10 ±0.20 3.92 ±0.20 c (26) 4.25 ±0.30 c (37) 4.60±0.20c (48)
8b 2.73 ±0.10 3.15 ±0.10 c (15) 3.29 ±0.20 c (20) 3.60 ±0.20 c (31)
8c 2.80 ± 0.10 3.85 ± 0.10 c (37) 4.15 ± 0.20c (48) 4.42 ± 0.30c (57)
8d 3.10 ± 0.20 3.75 ± 0.20 c (20) 3.93 ± 0.10 c (26) 4.05 ± 0.30c (30)
8e 3.05±0.20 3.82 ±0.30 c (25) 4.12 ±0.20 c (35) 4.35 ±0.20 c (42)
8f 3.08 ±0.10 4.28±0.20 c (38) 4.38 ±0.20 c (42) 4.58 ±0.20 c (48)
9a 3.15 ± 0.10 3.63 ± 0.20 c (15) 3.85 ± 0.10 c (22) 3.94 ± 0.10c (25)
9b 2.73± 0.20 3.71 ± 0.20c (43) 3.92 ± 0.10c (43) 3.96 ± 0.20c (45)
9c 2.89 ±0.20 3.68 ±0.20 c (27) 3.79 ±0.20 c (31) 4.02 ±0.20c (39)
10a 2.85 ± 0.20 3.95± 0.10c (38) 4.15 ± 0.20c (45) 4.35 ± 0.20c (52)
10b 2.92 ± 0.10 4.05 ± 0.20c (38) 4.12 ± 0.20c (41) 4.25 ± 0.20c (45)
10c 2.74 ± 0.10 3.94 ± 0.20c (43) 4.04 ± 0.30c (47) 4.15± 0.30c (51)
11a 2.64 ± 0.10 3.24 ± 0.10c (22) 3.28 ± 0.20c (24) 3.42 ± 0.20c (29)
11b 2.82 ± 0.10 3.25 ± 0.10 c (15) 3.40 ± 0.20c (20) 3.69 ± 0.20c (30)
11c 3.10 ± 0.10 4.20 ± 0.30c (35) 4.42± 0.20c (42) 4.71± 0.20c (51)
Diclofenac Na 2.78 ± 0.10 3.89 ± 0.30c (39) 4.09 ± 0.10c (47) 4.33 ± 0.20c (55)

a Dose levels, po: test compounds (20 mg / kg b.wt.), diclophenac Na (20 mg / kg b.wt.).
b Values are expressed as mean ± S.E. (Number of animals N = 5 rats).
c Significantly different compared to corresponding control.P ≤ 0.05.
d Between parentheses (Percentage analgesic activity).