Table 1.: The use of immunoneutralization of glucagon receptors by monoclonal antibody.

Dosage 1 - 30 mg/kg (monoclonal antibody) References
Mode of delivery Subcutaneous (s.c.) [18-21]
Efficacy Single s.c. injection of 3 mg/kg body weight maintained normoglycemia for 8 days.
30 mg/kg body weight achieved a longer duration of normoglycemia. No hypoglycemia was recorded.
Monoclonal antibody against glucagon receptors was ineffective in the face of severe hyperglycemia
without the addition of insulin.

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