Table 1: HIV-1 Isolates, Coreceptor Usage, Clinical History of the Study Subject and Corresponding Laboratory Studies

HIV-1 Isolate Date of Blood Sample CD4+ T-Cell Count (Cells/μl) Plasma Viral Load (RNA Copies/ml) Coreceptor Usage of HIV-1 Isolate* Clinical History*
D36 II 5/1995 NT 1400 R5X4 Diagnosed with HIVD 12/1998
D36 V 7/1996 414 2600 R5X4
D36 VIII 5/1997 540 4000 R5X4 ABC, AZT, NVP (1/1999-9/2004)
D36 IX 12/1997 390 7500 R5X4
D36 X 7/1998 325 NT R5X4 ABC, NVP, 3TC (9/2004-present)
D36 XI 1/1999 160 9900 R5X4

CD4+ T-cells were measured by flow cytometry. Plasma HIV-1 RNA was measured by COBAS Amplicor HIV-1 Monitor Version 1.0 (Roche Molecular Diagnostic Systems, Branchburg, N.J.). NT, not tested; HIVD, HIV-associated dementia; ABC, abavavir; AZT, zidovudine; NVP, nevirapine; 3TC, lamivudine. *These results have been reported previously [31, 18].