Article |
Studying |
Results |
P value |
Schlievert, et al., 1998 [13] |
Asc10 and EBS |
The combination of Asc10 and EBS increase lethality. |
0.0002 |
Chuang, et al., 2008 [4] |
Asc10 |
A double RGD mutant exhibited virulence equivalent to that of a strain carrying the prgB null allele. |
≤ 0.01 |
The N-terminal RGD motif is more important for virulence than the C-terminal RGD motif. |
≤ 0.01 |
Strains with mutations to the aggregation domains are more virulent than double RGD motif mutants. |
≤ 0.01 |
Chuang-Smith, et al., 2010 [5] |
Asc10 |
After 4 hours the Asc10- strain colonized heart valves at 40% the level of the Asc10+ strain. |
n/a* |
Several mutations had less severe impact on virulence in the ex vivo model. |
≤ 0.02 |
Chow, et al., 1993 [14] |
Asa1 and hemolysin |
Strains expressing Asa1 and hemolysin exhibited the highest rabbit mortality. |
< 0.01 |
Asa1+ strains produces vegetations weighing more than those produced by Asa1- strains. |
< 0.01 |
Haller, et al., 2014 [15] |
Cell-wall glycolipids |
bgsA mutants produced vegetations that weighed less than the wild type. |
< 0.35 |
bgsB mutants produced vegetations that weighed less than the wild type. |
< 0.05 |
bgsA and bgsB mutants produced vegetations that contained less CFU/gram than the wild type. |
< 0.0159 |
Nannini, et al., 2005 [7] |
Gls24 |
A Gls24 mutant was outnumbered by its parental strain at both time points in an endocarditis model. |
< 0.001 |
Nallapareddy, et al., 2006 [9] |
Ebp pili |
Mutant strains exhibited markedly reduced biofilm formation. |
< 0.001 |
Mutant strains were attenuated compared to the parental strain in a 2 hours in vitro attachment assay. |
< 0.001 |
An EbpA mutant was outnumbered by its parental strain in an endocarditis model. |
0.0069 |
Thurlow, et al., 2010 [6] |
GelE |
Mutations to GelE significantly decreased the mean CFU per gram of heart tissue |
< 0.05 |
Mutations to GelE significantly increases the matrix layer |
< 0.05 |
Singh, et al., 2010 [3] |
Ace |
Ace- strains were highly attenuated in adherence to collagen type I and IV compared to Ace+ strains |
< 0.0001 |
OG1RFΔace was outnumbered by OG1RF in a mixed endocarditis model |
< 0.0001 |
At 4 hours pAT392 produced vegetations with less CFU/geometric mean than pAT392::ace |
0.0417 |
Singh, et al., 2015 [2] |
EfbA |
TX5707 mutant showed a 44% decrease in whole cell binding to immobilized fibronectin |
< 0.0001 |
TX5707 produced biofilms with a 15% reduced density compared to OG1RF and TX5708 |
< 0.0001 |
At 48 hours TX5707 was outnumbered by OG1RF in a mixed endocarditis model |
< 0.0006 |
At 48 hours TX5707 was outnumbered by TX5708 om a mixed endocarditis model |
< 0.0086 |
Frank, et al., 2011 [16] |
Eep |
OG1RFΔeep exhibited a 4-log10 decrease in valve bacterial load compared to OG1RF |
0.003 |
OG1RFΔeep produced smaller vegetations (mean 8.8 mg) than OG1RF (mean 47.6 mg) |
0.0065 |
A complemented strain produced larger vegetations (mean 32.1) than OG1RFΔeep (mean 8.8 mg) |
0.027 |
* n/a indicates that the corresponding p-value is not presented in the article. |