Table 2: Univariate and multivariate analyses of risk factors for acquisition of fluoroquinolone or aminoglycoside resistance in addition to imipenem resistance in Pseudomonas aeruginosa.
|
Univariate analysis |
Multivariate analysis |
| OR |
95%CI |
P |
OR |
95%CI |
P |
| Resistance to FQs |
|
|
|
|
|
|
| Transplantation |
1.74 |
0.80-3.78 |
0.161 |
|
|
|
| Use of corticosteroids (≥5 mg/day) or other immunosuppressive agents |
1.81 |
0.93-3.52 |
0.082 |
|
|
|
| Surgery |
0.65 |
0.35-1.21 |
0.173 |
|
|
|
| Exposure to first-generation cephalosporins |
0.60 |
0.30-1.19 |
0.143 |
|
|
|
| Exposure to second-generation cephalosporins |
0.28 |
0.08-1.01 |
0.051 |
|
|
|
| Exposure to FQs |
5.30 |
2.52-11.14 |
<0.001 |
5.73 |
2.67-12.30 |
<0.001 |
| Exposure to AGs |
3.92 |
1.30-11.87 |
0.016 |
|
|
|
| MBL production |
6.67 |
1.78-24.91 |
0.005 |
7.90 |
2.01-31.04 |
0.003 |
| Resistance to AGs |
|
|
|
|
|
|
| Use of anticancer drugs |
2.57 |
0.64-10.40 |
0.184 |
|
|
|
| Use of urinary catheter |
0.42 |
0.13-1.38 |
0.152 |
|
|
|
| Exposure to antipseudomonal penicillins |
0.24 |
0.05-1.14 |
0.073 |
0.16 |
0.03-0.89 |
0.036 |
| Exposure to AGs |
6.04 |
1.59-23.00 |
0.008 |
9.00 |
1.92-42.19 |
0.005 |
| MBL production |
7.35 |
1.89-28.65 |
0.004 |
8.49 |
1.87-38.52 |
0.006 |
OR, odds ratio; CI, confidence interval; FQs, fluoroquinolones; AGs, aminoglycosides; MBL, metallo-β-lactamase