Table 3: Optimal cut-off value of selected non-invasive biomarkers, used to identify liver fibrosis.

- FIB-4 APRI AAR AARPRI
Training cohort
Cut-off 1.159 0.512 0.411 0.365
Sensitivity 83 84 63 83
Specificity 87 67 45 72
External cohort
Sensitivity 82 88 72 81
Specificity 78 66 55 78
Internal cohort
Sensitivity 86 81 66 88
Specificity 81 66 53 74

FIB-4; Fibrosis-4, APRI; AST to Platelet ratio index, AAR; AST to ALT ratio, AARPRI; AAR to Platelet ratio.

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