Cancer understudy | Phylum | Genus/species | Main findings | N | Technology used | Case sample | Control Sample | Reference |
---|---|---|---|---|---|---|---|---|
HNSCC | Fusobacterium | Leptotrichia buccalis | Relative abundance decreased in HNSCC samples compared to samples from healthy controls from JHU and HMP | 17 HNSCC patients, and 25 healthy controls (JHU Cohort). 154 participants of the Human Microbiome Project (HMP) |
16S rRNA next-generation sequencing | Saliva from HNSCC patients | Saliva from healthy controls | Guerrero-Preston et al., 2017 [62] |
OC | Actinobacteria | Rothia | Relative abundance significantly decreased in cancer patients compared to healthy matching tissue | 10 cancer patients, and 8 pre-cancer patients | 16S rRNA pyrosequencing | Tumour sample from cancer and pre-cancer patients | Contralateral healthy tissue from the same patients | Schmidt et al., 2014 [58] |
Firmicutes | Streptococcus | Relative abundance significantly decreased in cancer and pre-cancer patients compared to healthy matching tissue | ||||||
OPMD | Bacteroidetes | Porphyromonas gingivalis | Presence not found in OPMD lesions but presented in healthy tissue | 7 patients | Metagenomic sequencing | Tumour sample | Healthy tissue from the same patient | Decsi et al., 2018 [61] |
Prevotella bergensis | ||||||||
Firmicutes | Gemella haemolysans | Relative abundance markedly decreased in tumorous samples compared to healthy tissue | ||||||
Streptococcus mitis | ||||||||
Proteobacteria | Neisseria meningitidis | Presence not found in OPMD lesions but presented in healthy tissue | ||||||
Neisseria subflava | ||||||||
OSCC | Firmicutes | Granulicatella adiacens | Relative abundance decreased in OSCC lesions compared to healthy tissue | 10 patients | 16S rRNA sequencing | Tumour sample | Healthy tissue from the same patient | Pushalkar et al., 2012 [65] |
Streptococcus mitis | ||||||||
Actinobacteria | Rothia mucilaginosa | Presence predominantly associated with controls | 20 OSCC patients, and 20 matching controls | 16S rRNA sequencing | Tumour sample | Anatomical matching sites from healthy controls | Al-Hebshi et al., 2017 [59] | |
Firmicutes | Streptococcus mitis | |||||||
Actinobacteria | Rothia mucilaginosa | Relative abundance decreased in tumorous samples compared to healthy tissue | 20 patients | 16S rRNA sequencing | Tumour sample | Healthy tissue from the same patient | Hooper et al., 2006 [64] | |
Bacteroidetes | Prevotella veroralis | Presence not found in OSCC lesions but presented in healthy tissue | ||||||
Firmicutes | Streptococcus mitis | Relative abundance decreased in tumorous samples compared to healthy tissue | ||||||
Streptococcus salivarius | ||||||||
Bacteroidetes | Porphyromonas gingivalis | Presence not found in OSCC samples but presented in healthy tissue | 10 patients | 16S rRNA sequencing | Tumour sample | Non-tumorous mucosal tissue specimen from the same patient | Hooper et al., 2007 [66] | |
OSCC | Firmicutes | Granulicatella adiacens | Relative abundance decreased in tumorous samples compared to healthy tissue | |||||
Streptococcus mitis/oralis | ||||||||
Bacteroidetes | Capnocytophaga | Relative abundance decreased in OSCC lesions compared to healthy tissue | 3 patients, and 2 controls | 16S rRNA pyrosequencing | Saliva sample from cases | Saliva sample from healthy control | Pushalkar et al., 2011 [63] | |
Prevotella | ||||||||
Fusobacteria | Leptotrichia | |||||||
Proteobacteria | Neisseria | |||||||
Actinobacteria | Rothia | Relative abundance markedly decreased in OSCC samples compared to healthy control samples | 40 patients | Metagenomic sequencing | Swabs from oral lesions | Swabs from anatomically matching healthy sites | Zhao et al., 2017 [57] | |
Firmicutes | Granulicatella | |||||||
Streptococcus |