Oral Microbiota Associated with Oral and Gastroenteric Cancer

Table 3: Oral bacteria associated with esophageal cancers.

Cancer	Phylum	Genus/species	Main findings	N	Technology used	Case sample	Control sample	Reference
ESCC	Bacteroidetes	Porphyromonas gingivalis	Presence associated with a higher risk of ESCC	ESCC: 25 cases, and 25 controls EAC: 81 cases, and 79 controls	16S rRNA sequencing	Pre-diagnostic oral mouthwash from patients	Pre-diagnostic oral mouthwash from matching controls	Peters et al., 2017 [⁷³]
	Bacteroidetes	Porphyromonas	Relative abundance increased in the ESCC group compared to non-ESCC groups	87 diagnosed ESCC, 63 patients with dysplasia, and 85 healthy controls	16S rRNA pyrosequencing	Saliva sample from cases	Saliva sample from controls	Chen et al., 2015 [⁷²]
	Bacteroidetes	Prevotella
	Firmicutes	Streptococcus