Neutralizing epitope of the Fusion Protein of Respiratory Syncytial Virus Embedded in the HA Molecule of LAIV Virus is not Sufficient to Prevent RS Virus Pulmonary Replication but Ameliorates Lung Pathology following RSV Infection in Mice

Fig. (1) Generation of recombinant LAIV+HA/RSV viruses and expression of the RSV epitope. A. Schematic representation of chimeric HA+RSV-F_243-294 proteins. B. Western Blot analysis of recombinant LAIV+HA/RSV viruses using anti-influenza polyclonal antisera and anti-RSV monoclonal antibody Palivizumab. C. 3D modelling of the RSV-F_243-294+linker fragments generated using the i-TASSER algorithm.