Fig. (1).Schematic representation of the topology of Pmp23. White box corresponds to the fusion protein glutathione-S-transferase (GST) and the thrombin site is indicated by an arrow. The light grey box figures the Pmp23 protein (residues 1 to 204) composed by: the cytoplasmic region (residues 1 to 7), the transmembrane anchor (resi-dues 8 to 18) and the PECACE domain (dark grey, residues 36 to 140). The asterisk indicates the potential catalytic glutamate E61.