Fig. (6) Schematic illustrating rhodanese paralogs found in E. coli. The Abbreviations used are: Rhd, rhodanese homology domain; Rhd*, rhodanese homology domain in which an aspartate replaces the conserved active site cysteine of Rhd; ss, cleaved signal sequence of PspE; memb; hydrophobic segment of YgaP; FL, THUMP and PP-loop are the ferredoxin-like domain, RNA-binding domain found in RNA base-modifying enzymes, and ATP pyrophosphatase domains, respectively, of ThiI [54]; ATP-binding, domain of tRNA 2-selenouridine synthase involved in nucleotide binding, tRNA interaction and modification; H, hypothetical domain of unknown function; Cys-rich, cysteine-rich domain of YceA.