Fig. (6) Simplified scheme of lysoPtdCho metabolism in Saccharomyces cerevisiae. Abbreviations are:LysoPtDCho (lysophosphatidylcholine), GroPCho (glycerophosphocholine), PtDCho (phosphatidylcholine), LPCAT (lysophosphylcholine:acyl-CoA acyltransferase), mtTaz1 (mitochondrial acyl-CoA-independent LPCAT; [25]; Plb1p, Plb2p, Plb3p (phopholipases B1, B2 and B3), Nte1p (neuropathy target esterase); Dnf1p and Dnf2p (aminophospholipid translocating P-type ATPases 1 and 2, respectively); Lem3p (noncatalytic β subunit of Dnf1p and Dnf2p); GPCAT (glycerophosphocholine acyltransferase); LRO1 (phospholipid:diacylglycerol acyltransferase; PDAT; [19, 26]; Git1P (glycerophosphoinositol/glycerophosphocholine transporter; [27]. Not shown in schematic: PLBs are also involved in the hydrolysis of PC and PI to produce extracellular glycerophosphocholine and glycerophophoinositol, respectively [28].