Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis

Table 2: Summary of Pharmacokinetic Data in Three Animal Species Dosed with Ciprofloxacin or Levofloxacin

Regimen (Drug-mg/kg-Route)	C_max (µg/ml)	T_max (h)	AUC_0-6h (µg·h/ml)	AUC_0-∞h (µg·h/ml)	T_½ (h)	TBC (ml/min)
Swiss-Webster Mice
Cip-90-ip	25.5 ± 4.5^@	0.25	56.5	62.1	1.8	0.80
Lev-5-ip	13.4 ± 6.3	0.25	14.6	16.7	2.1	0.17
Lev-90-ip	45.2 ± 10.3^#^{, @}	0.25	36.2	37.4	1.7	1.33
Hartley Guinea Pigs
Cip-15-sc	2.2 ± 1.0	1.0 (0.25-1.5)	5.0 ± 0.6	5.5 ± 0.7	1.4 ± 0.2	18.0 ± 2.4
Lev-8.5-sc	2.7 ± 2.1	1.0 (0.25-1.5)	3.8 ± 0.9	6.6 ± 3.3	1.7 ± 0.6	10.5 ± 4.2
Dutch-Belted Rabbits
Cip-10-im	2.3 ± 1.5	0.63 (0.25-2)	3.2 ± 0.5	5.3 ± 1.9	1.5 ± 0.7	32.9 ± 11.7
Lev-7.1-im	1.2 ± 0.2	1.25 (1-1.5)	3.3 ± 0.5	5.1 ± 1.7	2.8 ± 1.2^*	31.3 ± 10.1

Data given as mean ± S.D except Tmax given as median (range);

^* P=0.009, Lev-7.1 vs Cip-10;

^# P=0.013, Lev-90 vs Cip-90;

^@ P=<0.001, Cip-90 and Lev-90 vs Lev-5.

Note: composite nature of most PK parameters in mice prevents statistical analysis.AUC = Area Under Curve (Total drug exposure over time course).TBC = Total Body Clearance.