Table 3: Summary of In Vivo ED50 and ED100 Values During Treatment with Fluoroquinolones Against B. anthracis, Y. pestis, and F. tularensis Following Challenge by Nasal Instillation
ED50 (mg/kg/day) / ED100 (mg/kg/day) |
Animal |
Antibiotic |
B. anthracis Ames Spores |
Y. pestis CO92 Cells |
F. tularensis SCHU S4 Cells |
Swiss-Webster Mice |
Ciprofloxacin |
70/90 |
N.D. |
N.D. |
Levofloxacin |
28/90 |
0.7/5.0 |
0.1/5.0 |
Hartley Guinea Pig |
Ciprofloxacin |
8.8/15 |
N.D. |
N.D. |
Levofloxacin |
5.0/17 |
N.D. |
N.D. |
Dutch-belted Rabbit |
Ciprofloxacin |
7.5/10 |
N.D. |
N.D. |
Levofloxacin |
4.0/7.0 |
N.D. |
N.D. |