| Risk Factors | PICNIC Study (2004) [16] 33- 35 GA n=1758 | FLIP Study (2004) [48] 33- 35 GA n= 186 | FLIP- 2 Study (2008) [17] 33-35 GA n= 202 | Other Studies |
|---|---|---|---|---|
| Age < 6 months at the beginning of the RSV season | not performed | Age < 10 weeks | Age < 10 weeks | Law, et al. (2003) [46] |
| OR 3.75 (2.59- 5.45); | P= 0.0 | |||
| OR 2.99 (2.23- 4.01); | P= 2.11*E -13 | |||
| Multiple Birth | not performed | N= 64 (34.4%) | N= 76 (37.6%) | Simoes, et al. (1993) [49] |
| P= 0.761 | P=0.083 | Resch, et al. (2005) [15] | ||
| Male Sex | OR 1.91 (1.10-3.31); | N= 117 (62.9%); | N= 121 (59.9%); | |
| P= 0.02 | P= 0.057 | P= 0.083 | ||
| Low socioeconomic status and parental education | not performed | No school or primary: | not performed | Jansson, et al. (2002) [51] |
| N=60 (32.3%) | Anderson, et al. (1988) [52] | |||
| High school or university: | Mc Connockie (1986) [53] | |||
| N= 126 (67,8%) | Holberg, et al. (1991) [54] | |||
| Crowded living conditions/siblings | > 5 individuals in the home | > 4 residents and visitors | > 4 residents and visitors | Liese, et al. (2003) [25] |
| OR 1.69 (0.93-3.10); | OR 1.91 (1.19-3.07); P= 0.0074 | OR 1.37 (0.85-2.20); | ||
| P= 0.088 | School age siblings ≥ 1 | P= 0.238 | ||
| Preschool age siblings | OR 2.85 (1.88-4.33); P= 9.4*E -7 | School age siblings/day care attendance | ||
| OR 2.76 (1.51-5.03); | OR 2.04 (1.53-2.74); | |||
| P= 0.001 | P= 1.47*E -6 | |||
| Maternal smoking and indoor smoke pollution | ≥ 2 smokers in the household | Tobacco smoke at home | Tobacco smoking during pregnancy | |
| OR 1.71 (0.97-3.00); | OR 0.95 (0.66-1.36); P= 0.859 | OR 1.61(1.16-2.25); P= 0.0044 | ||
| P= 0.064 | Mother smoking | |||
| OR 1.49 (1.01-2.18); P= 0.055 | ||||
| ³ 2 smokers | ||||
| OR 1.41 (0.92-2.14); P = 0.146 | ||||
| Malnutrition/ Small for gestational age | OR 2.19 (1.14-4.22); | not performed | not performed | |
| P= 0.019 | ||||
| Family history of atopy of asthma | OR 0.42 (0.18-0.996); P=0.049 | Family history of wheezing | Family history of wheezing | |
| OR 1.90 (1.19-3.01); P= 0.0068 | OR 1.22 (0.89-1.66); P= 0.236 | |||
| Low cord serum antibody titers | not performed | not performed | not performed | Stensballe, et al. (2009) [56] |
| Stensballe, et al. (2003) [57] | ||||