Table 2.: Protection in mice against challenge with 100 MID50 (~6 log10 EID50) of wild type virus A/Mallard/Netherlands/ 12/00(H7N3) following immunization with H7N3 LAIV1.

Preparation Survived on day 14 p.i./ total Mean % of weight loss on day 6 p.i. Virus isolation from tissues at day 3 pi
Lungs Nasal turbinates Brain Spleen
No/ total Virus titers (log10EID50/mL) No/ total Virus titers  (log10EID50/mL) No/ total Virus titers (log10EID50/mL) No/ total Virus titers (log10EID50/mL)
H7N3 LAIV 1000 MID50 5/5 1 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0
H7N3 LAIV 100 MID50 5/5 6 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0
PBS 5/5 9 3/3 5.7 ±1.3 3/3 4.2 ±0.3 0/3 ≤1.5±0.0 0/3 ≤1.5±0.0

1 Challenge was done 21 days after 2nd vaccine dose
2 P=0.049 compared to vaccinated mice
3 P=0.007 compared to vaccinated mice