Vaccine group | No.of ferrets | HI titers (GMT) after immunization : | Challenge on 14 days after second vaccine dose | Challenge virus isolation at day 3 pi | ||||
---|---|---|---|---|---|---|---|---|
Lungs | Nasal washes | |||||||
One dose | Two doses | No/total | Mean virus titer (log10PFU ml-1 ±SD) | No/total | Mean virus titer (log10PFU ml-1 ±SD) |
|||
H7N3 LAIV 107 EID50 | 6 | 23.3 | 186.7 | wt H7N3 107 EID50 | 0/3 | 0±0.0 | 0/3 | 0±0.0 |
H7N3 LAIV 107 EID50 | 6 | 11.6 | 173.3 | PBS | 0/3 | 0±0.0 | 0/3 | 0±0.0 |
PBS | 6 | ≤10.0 | ≤10.0 | wt H7N3 107 EID50 | 1/3 | 1.3±0.5 | 3/3 | 3.0±0.9 |
PBS | 6 | ≤10.0 | ≤10.0 | PBS | 0/3 | 0±0.0 | 0/3 | 0±0.0 |