Table 2.: Rate of neuraminidase (NA) gene segment inheritance by reassortants of master donor viruses (MDV) with wild-type (WT) influenza viruses of varying sensitivity to non-specific, heat-stable inhibitors in guinea pig serum.

WT Parental Strain1 Reassortants Generated2
Strain Designation Sensitivity to Inhibitors Total NA Gene From
WT Parent MDV
Influenza A (H3N2) Viruses
A/ Hong Kong/1186/03 Resistant 8 8 0
A/Wyoming/3/03 Resistant 4 4 0
A/California/07/04 Resistant 27 26 1
A/Wisconsin/67/05 Resistant 19 17 2
A/Victoria/361/11 Resistant 16 16 0
A/Nanchang/933/95 Sensitive 9 9 0
A/Sydney/5/97 Sensitive 58 2 56
A/Panama/2007/99 Sensitive 7 1 6
A/Wellington/01/04 Sensitive 30 9 21
A/Malaysia/01/04 Sensitive 8 2 6
A/Brisbane/10/07 Sensitive 14 3 11
Influenza A (H1N1) Viruses
A/Beijing/262/95 Resistant 18 15 3
A/Perth/13/95 Resistant 7 7 0
A/Johannesburg/82/96 Resistant 6 6 0
A/Brisbane/59/07 Resistant 13 11 2
A/New Caledonia/20/99 Resistant 50 50 0
A/Solomon Islands/03/06 Resistant 8 8 0
A/California/07/09 Resistant 34 33 1
Influenza A (H2N2) Viruses
A/ California/1/66 Resistant 5 5 0
A/Tokyo/3/67 Sensitive 29 29 0
Influenza A (H5N1) Viruses
NIBRG-23 Sensitive 123 12 0
VN1203 Resistant 42 14 28
INDO/05 Resistant 11 0 11
Influenza B Viruses
B/Shandong/7/97 Resistant 8 8 0
B/Hong Kong/330/01 Resistant 6 6 0
B/Malaysia/2506/04 Resistant 29 27 2
B/Ohio/01/05 Resistant 17 17 0
B/Brisbane/60/08 Resistant 16 14 2
Influenza B Viruses
B/Texas/26/08 Resistant 12 5 7
B/Harbin/07/94 Sensitive 4 3 1
B/Petersburg/92/95 Sensitive 8 3 5
B/Johannesburg/05/99 Sensitive 14 5 9
B/Jilin/20/03 Sensitive 10 4 6
B/Jangsu/10/03 Sensitive 23 9 14
B/Florida/7/04 Sensitive 14 5 9
B/Florida/4/06 Sensitive 31 3 28
B/Brisbane/3/07 Sensitive 13 1 12
B/Wisconsin/1/10 Sensitive 140 4 136
B/Bangladesh/1994/10 Sensitive 57 19 38
B/Texas/6/11 Sensitive 12 7 5

1WT parental virus. 2All reassortants inherited HA of WT viruses. 3Virus NIBRG-23 (H5N1) did not reassort with MDV when classical reassortment procedures were used; all 12 clones isolated were identical to NIBRG-23 (H5N1) in genomic composition.