Table 2: Sensitivity, specificity and accuracy for TNF-α, MMP-2 and MMP-9 in fibrotic cases (F1-F3) and cirrhotic cases (F4).

Cut-off F1-F3
(No. of cases)
F4
(No. of cases)
AUC p Sensitivity Specificity PPV NPV Accuracy
TNF-α >0.33 13 6 0.563* 0.598 40.0 86.67 66.67 68.42 68.0
≤0.33 2 4
MMP-2 >0.74 8 2 0.667* 0.166 80.0 53.33 53.33 80.0 64.0
≤0.74 7 8
MMP-9 ≤3.25 4 1 0.670* 0.157 90.0 26.67 45.0 80.0 52.0
>3.25 11 9

AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value.
* AUC closer to 1 means higher diagnostic performance.