Table 1: Model-Centric Approaches for Guideline Specification and Application

System Name		Supports Automatic Guideline Application	Provides Gradual Methodological Specification	Includes Tools to Support the Formal Specification	Includes a Guideline Central Repository
ONCOCIN [13, 14]	1970	+	-	-	-
EON [15]	1996	+	-	+	-
GLIF [16-18]	1998	+	-	+	-
PROforma [19, 20]	1998	+	-	+	-
Asbru [21-23]	1998	+	-	-	-
Prodigy [24, 25]	2000	+	-	+	-
GUIDE [26, 27]	2001	+	-	+	+
GLARE [28]	2002	+	-	+	-
SAGE [29]	2004	+	-	+	-
GASTON [30]	2004	+	-	+	-
Helen [31]	2005	+	-	+	-
SEBASTIAN [32]	2005	+	-	-	-