Table 2: Experimental and human regarding the role of cannabidiol in different model of epilepsy.

Compound	Type of animal model	Results	References
Phytocannabinoid cannabidivarin (CBDV)	1) Epileptiform local field potentials (LFPs) 2) Maximal electroshock (MES) 3) Audiogenic seizures in mice 4) Pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats	CBDV is an effective anticonvulsant in a broad range of seizure models	[61]
Phytocannabinoid cannabidivarin (CBDV)	1) Audiogenic seizures in mice 2) Pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats	CBDV induces significant anticonvulsant effects in all three seizure models	[62]
Phytocannabinoid cannabidivarin (CBDV)	Pentylenetetrazole (PTZ)-induced seizures in rats	CBDV induces significant anticonvulsant effects on PTZ seizure	[63]
Phytocannabinoid cannabidivarin (CBDV)	Epileptiform neuronal spike activity in hippocampal brain slices exposed to a Mg(2+)-free solution	CBDV reduced epileptiform burst amplitude and duration	[64]
WIN55.212-2 and URB597	Amygdala kindling model of temporal lobe epilepsy	WIN55.212-2 significantly delayed the progression of seizure severity, whereas URB597 did not affect seizure development	[65]
Human data	Twelve patients with refractory mesial temporal lobe epilepsy due to hippocampal sclerosis received a [(18)F]MK-9470 scan to assess the in vivo availability type 1 cannabinoid (CB1) receptor	CB1 receptor availability showed opposite changes in different brain regions that are involved by complex partial seizures in refractory mesial temporal lobe epilepsy with hippocampal sclerosis	[66]
Human data	Comparative expression profiling and quantitative electron microscopic analysis of postmortem samples from subjects with no signs of neurological disorders (controls) and surgical specimens of epileptic hippocampal tissue removed from patients with intractable temporal lobe epilepsy	The impaired neuroprotective effects of endocannabinoids in human epileptic hippocampus suggest that downregulation of type 1 cannabinoid receptor and related molecular components of the endocannabinoid system may compound the harmful effects of network hyperexcitability	[67]
Human data	Measurement of endocannabinoid levels in cerebrospinal fluid (CSF) of drug-naive patients with temporal lobe epilepsy	Patients exhibited significantly reducted CSF anandamide levels compared with healthy controls	[68]