Table 1: Receptors Present at the Level of Sensory Primary Neurons and Possible Effects on the Release of Neuropeptides Involved in Neurogenic Inflammation and Migraine Pain

RECEPTORS LIGANDS ACTIVITY ON THE SENSORY PRIMARY NEURON
5-HT1-D SEROTONIN DECREASED RELEASE OF CGRP AND SUBSTANCE P
GABA-A GABA DECREASED RELEASE OF CGRP AND SUBSTANCE P
CB-1 ANANDAMIDE* DECREASED RELEASE OF CGRP AND SUBSTANCE P
VR-1 CAPSAICIN OR ANANDAMIDE** INCREASED RELEASE OF CGRP AND SUBSTANCE P
PAR-2 PEPTIDIC CHAINS SLIGRL AND SLIGKV INCREASED RELEASE OF CGRP AND SUBSTANCE P

* At nanomolar concentrations.
** At micromolar concentrations.