Table 1: Animal Models for Studying Risk Factors and Therapies for Stroke

Model for Model name Animal species available Gene/s involved
Hypercholesterolemia ApoE deficient mouse Mouse ApoE
ApoB mutant mouse Mouse ApoB
LDLR deficient mouse Mouse LDLR
Hyperhomocysteinemia CBS deficient mouse Mouse CBS
MTHFR deficient mouse Mouse MTHFR
Primary hypertension SHR Rat Gene not known
SHR-SP Rat Gene not known
Ren-2 transgenic rat (TGR-mREN2)27 Rat Ren-2
Dahl sensitive rat Rat ACE and ANF
Secondary hypertension Two- kidney one clip Dog, rat, mouse -
One- kidney one clip Dog, rat, mouse -
Age Spontaneously aged (> 18 months) Rat, mouse -
Senescence-accelerated mice Mouse Genes not known
CADASIL CADASIL transgenic mouse Mouse Notch 3

Abbreviations: ApoE, apolipoprotein E; ApoB, apolipoproteinB; LDLR, Low density lipoprotein receptor; CBS, Cystathionine beta- synthetase; MTHFR, Methylenetetrahydrofolate reductase; SHR, Spontaneously hypertensive rat; SHR-SP, Spontaneously hypertensive rat- stroke prone; ACE, Angiotension converting exzyme; ANF, atrial natriuretic factor; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.