Table 1: Co-infections in Lyme Disease

Disease* Pathogen Mode of transmission Reservoir IC, EC
Tick-borne co-infections
HGA (HGE)
HME
Anaplasma phagocytophila
E. chaffeensis
Ticks Ixodes ricinus (Europe) Ixodes scapularis (USA) White- footed mouse (HGA)
Red deer, human beings (HME)
IC
Bartonellosis Bartonella henselae
(Bartonella quintana, Bartonella bacilliformis) [18-20]
Bite or scratch wounds of dog or cat (saliva, claws); cat fleas; lice (B. quintana) [21, 22], tick bite
Others: dust mites, flea bites, flea feces (oral infection), contact with cats, contact with dogs (paws, saliva, lice [21], flies, gadflies, blood transmission, mother-child transmission [23]
Cats [24-27], domestic and wild animals [28] IC
Rickettsiosis Mediterranian spotted fever Rickettsia helvetica Rickettsia conorii Ticks, mites, fleas, lice Ticks IC
Tularemia Francisella tularensis Mosquitos, gadflies, fleas, lice, mites, oral, inhalation Various vertebrates IC
Q fever Coxiella burnetii Oral or inhalation Cattle, milk, human beings IC
Babesiosis Babesia microti, Babesia divergens [29,30] Ixodes ricinus (Europe), Ixodes scapularis (USA) [29, 30], blood transfusions [31], perinatal [32, 33] Cattle (other vertebrates) IC
Other co-infections (not tick-borne)
Mycoplasma infections Mycoplasma pneumoniae Droplet infection, humans Human beings EC
Chlamydophila pneumoniae infection Chlamydophila pneumoniae Droplet infection, person to person Human beings IC&EC
Chlamydia trachomatis infection Chlamydia trachomatis Sexual contact Human beings IC&EC
Yersiniosis Yersinia enterocolitica
Yersinia pseudotuberculosis (USA)
Fecal-oral Various vertebrates IC&EC
Parvovirus B19 infection Human parvovirus B19 Respiratory tract: droplet infection, person to person, during pregnancy, blood transfusion Human beings IC
Campylobacter jejuni infection Campylobacter jejuni Fecal-oral
Game and domestic animals, particularly poultry, animal products, contaminated water
Vertebrates IC&EC

IC = Intracellular; HGA = : human granulocytic anaplasmosis ; HGE = human granulocytic erlichiosis;
* = Relevant co-infections are highlighted in bold.