Chronic Lyme Disease and Co-infections: Differential Diagnosis

Table 10: Disease Manifestations of Chronic Lyme Disease and Chronic Co-infections (Overview)

Disease	Symptomatology
	GenS	MuSk	NS	Skin	Heart	Eye	GI	UG	rA	GBS	LA
Lyme disease	+	+	+	+	+	+	+	+	(+)^*	+	+
Bartonellosis	+	+	+	+	+	+	+	+	+	+	+
Y. enterocolitica	(+)	+	+	+	+	+	+		+	+
M. pneumoniae	(+)	+	+	+	+	+	+	+	+	+
C. pneumoniae			+		+				+	+
C. trachomatis							+		+	+
C. jejuni									+	+

Y. enterocolitica = Yersinia enterocolitica; M. pneumoniae = Mycoplasma pneumoniae; C. pneumoniae = Chlamydophila pneumoniae; C. trachomatis = Chlamydia trachomatis, C. jejuni = Campylobacter jejuni; GenS = general symptoms (fatigue, head aches, lassitude); MuSk = musculoskeletal symptoms (arthritis, arthralgias, myalgias); NS = symptoms of the nervous system (CNS, polyneuropathy, radiculopathy); Skin = skin lesions (erythema migrans, ACA in cases of Lyme disease e.g. infected skin injury); LA = lymphadenopathy; Heart = heart disease (myocarditis, cardiomyopathy, pericarditis); Eye = eye disease (uveitis, conjunctivitis, optic neuritis); GI = gastrointestinal complaints; UG = urogenital symptoms; rA = reactive arthritis; GBS = Guillain-Baré syndrome; + = positive; (+) = presumption based on general symptoms in cases of yersiniosis and Mycoplasma pneumoniae infection;+

^{* =} probably chronic infectious, hypothetical autoimmune origin (mimicry).