Table 1: Mean MEMRI T1-signal intensity ratio, DTI FA percentage increase, and myelin load percentage change ± mean standard deviations.
Control
SCIH
P value (Control vs. SCIH)
SCIT
P value (Control vs. SCIT)*
MEMRI†
0.99±0.003
0.87±0.02
<0.001
0.62±0.01
<0.001
DTI FA‡
–6.1%±0.9%
40.1%±18.5%
0.019
67.5%±15.3%
0.002
Myelin load†
99.1%±1.0%
51.8%±4.0%
<0.001
38.7%±1.5%
<0.001
*Post hoc ANOVA Bonferroni test was used to calculate P values.
†Performed on experimental/control groups injected with MnCl2.
‡Performed on experimental/control groups not receiving MnCl2 injections.
Abbreviations: DTI FA, diffusion tensor imaging fractional anisotropy; MEMRI, manganese-enhanced MRI; SCIH, hemisection spinal cord injury; SCIT, transection spinal cord injury.