Table 2: The accumulation rate constant Kacc from the irreversible 2-compartment model “input-3k” and the unidirectional influx rate constant K1 from the reversible 2-comartment model “input-4k” in selected regions. Means and SDs are presented. The different groups are defined in the text. The standardized difference is described in the text

Region Used CBV Kacc (min-1) from irreversible 2-compartment model (input-3k) K1 (min-1) from reversible 2-compartment model (input-4k)
HC (n=3) HC-Hi (n=1) Hi (n=1) AD-Lo (n=3) AD-Hi (n=5) Stand diff AD-Hi-HC HC (n=3) HC-Hi (n=1) Hi (n=1) AD-Lo (n=3) AD-Hi (n=5) Stand. Diff.AD-Hi- HC
Whole brain 0.035 0.0175
0.0046		 0.0185 0.0274 0.0156
0.0016		 0.0326
0.0039		 3.55 0.28
0.05		 0.18 0.20 0.18
0.03		 0.18
0.04		 -2.34
PrVisual cortex 0.05 0.0127
0.0041		 0.0152 0.0223 0.0124
0.0021		 0.0359
0.0080		 3.65 0.38
0.04		 0.23 0.28 0.24
0.08		 0.27
0.06 		-2.15
Frontal cortex 0.05 0.0136
0.0031		 0.0221 0.0367 0.0145
0.0022		 0.0389
0.0062		 5.19 0.31
0.04		 0.19 0.23 0.19
0.02		 0.20
0.06		 -2.26
Parietal cortex 0.05 0.0148
0.0036		 0.0212 0.0313 0.0148
0.0024		 0.0369
0.0050		 5.04 0.32
0.04		 0.20 0.20 0.19
0.04		 0.16
0.05		 -3.46
Temporal cortex 0.05 0.0140
0.0040		 0.0151 0.0235 0.0132
0.0020		 0.0306
0.0040		 4.19 0.27
0.05		 0.17 0.17 0.15
0.02		 0.15
0.02		 -2.93
Putamen 0.04 0.0119
0.0037		 0.0148 0.0293 0.0149
0.0023		 0.0358
0.0023		 7.80 0.40
0.03		 0.27 0.30 0.26
0.03		 0.30
0.05		 -2.56
Thalamus 0.04 0.0132
0.0056		 0.0137 0.0274 0.0112
0.0037		 0.0243
0.0026		 2.56 0.35
0.04		 0.25 0.30 0.25
0.04		 0.30
0.09		 -0.68
Pons 0.02 0.0186
0.0062		 0.0159 0.0250 0.0197
0.0027		 0.0246
0.0053		 1.03 0.32
0.06		 0.19 0.23 0.19
0.04		 0.29
0.14		 -0.26
White matter 0.02 0.0250
0.0030		 0.0225 0.0179 0.0219
0.0015		 0.0312
0.0048		 1.56 0.17
0.05		 0.13 0.07 0.09
0.03		 0.10
0.02		 -2.03
Cerebellar cortex 0.05 0.0137
0.0051		 0.0086 0.0110 0.0107
0.0006		 0.0169
0.0042		 0.69 0.38
0.04		 0.25 0.32 0.22
0.04		 0.24
0.04		 -4.79