Fig. (1) Differences in baseline relative white matter volumes and their longitudinal changes between patients with schizophrenia and healthy subjects and between schizophrenia patients with good and poor outcomes^a.^a Significant between-group differences as assessed with Student’s t test for each Brodmann’s area (two-tailed p-values are color-coded in the bar). Baseline volumes: Blue colors denote areas with smaller relative white matter volumes in patients with schizophrenia than in healthy subjects and in poor-outcome patients in comparison to patients with good outcome at two-tailed p<0.05 (indigo) and p<0.1 (trend, light-blue). Brown color indicates areas with larger white matter volumes in patients with schizophrenia than in healthy subjects. Longitudinal changes (relative volumes at baseline scan minus relative volumes at follow-up scan): Green colors indicate areas with greater volume increase in healthy subjects than in schizophrenia patients at two-tailed p<0.05 (dark-green) and p<0.1 (trend, light-green). Red colors indicate areas with greater volume increase in poor-outcome patients than in patients with good outcome at p<0.05 (burgundy hue) and p<0.1 (trend, scarlet hue).