| Brodmann’s Area Contrasts |
Gray Matter Volumes |
White Matter Volumes |
Fractional Anisotropy |
| Frontal lobe |
| (4-6-8-9-10-11-12-24-25-32-44-45-46-47) |
|
|
|
| Schizophrenia vs. healthy subjects |
ME F1, 62=10.28, p=0.0002 |
|
|
|
g×BA F13, 806=2.65, p=0.001 (0.057) |
g×BA F13, 806=3.09, p=0.0002 (0.038) |
|
|
|
|
g×h×BA F13, 572=3.43, p=0.00004 (0.0008) |
| Good-outcome vs. poor-outcome |
|
g×h F1, 46=5.52, p=0.02 (0.02) |
g×h×BA F13, 403=3.77, p=0.00001 (0.0003) |
| Temporal lobe |
| (20-21-22-27-28-34-35-36-37-38-41-42) |
|
|
|
| Schizophrenia vs. healthy subjects |
ME F1, 62=11.55, p=0.001 |
|
|
|
g×BA F11, 682=3.77, p=0.00003 (0.003) |
|
|
| Good-outcome vs. poor-outcome |
|
ME F1, 46=8.10, p=0.007 |
|
|
g×h F1, 46=4.43, p=0.04 (0.04) |
g×h F1, 46=8.53, p=0.005 (0.005) |
|
|
|
g×BA F11, 506=1.95, p=0.03 (0.10) |
|
|
g×h×BA F11, 506=3.23, p=0.0003 (0.005) |
g×h×BA F11, 506=4.13, p=0.000008 (0.002) |
|
| Parietal lobe |
| (1/2/3/5-7a-7b-23-26-29-30-31-39-40-43) |
|
|
|
| Schizophrenia vs. healthy subjects |
ME F1, 62=4.9, p=0.03 |
|
ME F1, 44=4.52, p=0.04 |
|
g×BA F10, 620=2.05, p=0.03 (0.11) |
|
g×BA F10, 440=2.31, p=0.01 (0.05) |
|
g×h×BA F10, 620=2.06, p=0.025 (0.10) |
|
|
| Good-outcome vs. poor-outcome |
|
ME F1, 46=3.95, p=0.053 |
|
|
|
g×BA F10, 460=1.89, p=0.045 (0.13) |
g×BA F10, 310=2.59, p=0.005 (0.03) |
|
g×h×BA F10, 460=3.51, p=0.0002 (0.014) |
g×h×BA F10, 460=8.32, p=0000001 (0.000003) |
|
| Occipital lobe |
| (17-18-19) |
|
|
|
| Schizophrenia vs. healthy subjects |
|
|
|
| Good-outcome vs. poor-outcome |
g×h F1, 46=6.29, p=0.016 (0.016) |
g×h F1, 46=5.76, p=0.02 (0.02) |
g×h F1, 44=3.77, p=0.059 (0.059) |
| Cingulate gyrus |
| (23-24-25-26-29-30-31-32) |
|
|
|
| Schizophrenia vs. healthy subjects |
ME F1, 62=11.11, p=0.0015 |
|
|
|
|
g×h F1, 62=5.10, p=0.03 (0.03) |
|
|
g×BA F7, 434=6.32, p=0.0000001 (0.00003) |
g×BA F7, 434=2.33, p=0.02 (0.06) |
|
| Good-outcome vs. poor-outcome |
|
|
|
Abbreviations: ME – main effect of diagnosis, g×h – diagnostic group by hemisphere interaction, g×BA – diagnostic group by Brodmann’s area interaction, g×h×BA – diagnostic group by hemisphere by Brodmann’s area interaction.
Uncorrected p values are followed by Huynh-Feldt corrected p in parentheses. Interactions at trend level of significance (p<0.10) are in italics. Note that parietal areas 1, 2, 3, and 5 were combined in these analyses, hence 1/2/3/5.