| Brodmann’s Area Contrasts |
Fractional Anisotropya
|
Fractional Anisotropy Controlled for Illness Durationb
|
| Frontal lobe |
| (4-6-8-9-10-11-12-24-25-32-44-45-46-47) |
|
|
| Schizophrenia vs. healthy subjects |
g×t×h×BA F13, 559=2.92, p=0.0004 (0.002) |
|
| Good-outcome vs. poor-outcome |
g×t×BA F13, 390=2.16, p=0.01 (0.03) |
g×t×BA F13, 338=2.17, p=0.01 (0.029) |
| Temporal lobe |
| (20-21-22-27-28-34-35-36-37-38-41-42) |
g×t F1, 43=4.68, p=0.036 (0.036) |
|
| Schizophrenia vs. healthy subjects |
|
|
| Good-outcome vs. poor-outcome |
|
|
| Parietal lobe |
| (1/2/3/5-7a-7b-23-26-29-30-31-39-40-43) |
|
|
| Schizophrenia vs. healthy subjects |
|
|
| Good-outcome vs. poor-outcome |
g×t×BA F10, 300=2.49, p=0.007 (0.034) |
g×t×BA F10, 260=2.19, p=0.02 (0.057) |
|
g×t×h×BA F10, 300=2.58, p=0.005 (0.019) |
g×t×h×BA F10, 260=2.58, p=0.01 (0.036) |
| Occipital lobe |
| (17-18-19) |
|
|
| Schizophrenia vs. healthy subjects |
g×t F1, 30=4.85, p=0.036 (0.036) |
|
| Good-outcome vs. poor-outcome |
g×t×BA F2, 60=9.21, p=0.0003 (0.0003) |
g×t×BA F2, 52=7.49, p=0.001 (0.001) |
| Cingulate gyrus |
| (23-24-25-26-29-30-31-32) |
|
|
| Schizophrenia vs. healthy subjects |
|
|
| Good-outcome vs. poor-outcome |
g×t×h×BAF7, 210=2.11, p=0.044 (0.06)
|
|
|
Frontal (4-6-8-9-10-11-12-44-45-46-47) vs. |
|
temporal (20-21-22-27-28-34-35-36-38-41-42) vs. |
|
parietal (1/2/3/5-7a-7b-23-26-29-30-31-39-40-43) |
| Schizophrenia vs. healthy subjects |
g×t×r×BA F20, 600=1.74, p=0.02 (0.09) |
|
|
g×t×h×r×BA F20, 600=2.13, p=0.003 (0.02) |
|
| Good-outcome vs. poor-outcome |
g×t F1, 30=6.65, p=0.015 (0.015) |
g×t×h×r×BA F20, 520=1.90, p=0.01 (0.04) |
Abbreviations: g×t – diagnostic group by scan time interaction, g×t×BA – diagnostic group by time by Brodmann’s area interaction, g×t×h×BA – diagnostic group by time by hemisphere by Brodmann’s area interaction, g×t×r×BA – diagnostic group by time by region by Brodmann’s area interaction, g×t×h×r×BA – diagnostic group by time by hemisphere by region by Brodmann’s area interaction.
Uncorrected p values are followed by Huynh-Feldt corrected p in parentheses. Interactions at trend level of significance (p<0.10) are in italics. Note that parietal areas 1, 2, 3, and 5 were combined in these analyses, hence 1/2/3/5.
a ANCOVA with subjects’ age and interscan interval as covariates
b ANCOVA with subjects’ age, interscan interval and illness duration as covariates.