Fig. (3) Permanent MCAO: (a) cerebral blood flow (CBF, upper row) and apparent diffusion coefficient (ADC, lower row) maps of an ani-mal which underwent permanent occlusion. (b) Temporal evolution of lesion volumes were defined by abnormal CBF and ADC. The differ-ence between the two lines indicates the perfusion-diffusion mismatch. The grayscale bar indicates a CBF of 0 to 120 mL/100g/min and an ADC of 0 to 0.3 x 10^-3 mm²/sec.