Biofabricated Silver Nanoparticles Synergistically Activate Amphotericin B Against Mature Biofilm Forms of Candida Albicans

Table 4: Comparison of MICs of silver nanoparticles (SNPs) and Amphotericin B (AmB), alone and in combination, against planktonic and biofilm growth of C. albicans ATCC 90028 and C. albicans GMC 03.

Growth	MIC (µg/ml)
	Candida albicans ATCC 90028						Candida albicans GMC 03
	Alone		In Combination				Alone			In Combination
	SNPs	AmB	SNPs	AmB	FICI	Remarks	SNPs	AmB	SNPs		AmB	FICI	Remarks
Planktonic Growth	1.5	0.25	0.187	0.125	0.624	Additive	3	0.25	0.375		0.016	0.189	Synergistic
Biofilm Formation	50	1.00	3.125	0.125	0.187	Synergistic	50	1.00	25		0.25	0.75	Additive
Mature Biofilm	100	2.00	6.25	0.5	0.312	Synergistic	100	2	6.25		1.00	0.562	Additive