Table 1: Adopted variables levels in Box-Behnken design.

Independent variables / Factor Levels
-1 0 1
X1 = PLGA amount 25 75 125
X2 = PVA Concentration (%w/v) 0.25 0.75 1.25
X3 = Dichloromethane volume (mL) 2 4 6
Dependent variables / Response Constraints
Y1 = Particle size (nm) Minimum
Y2 = Percentage Drug entrapment (%w/w) Maximum
Y3= Poly Dispersibility Index Minimum