Development of Dry Powder Inhaler Containing Prothionamide-PLGA Nanoparticles Optimized Through Statistical Design: In-vivo Study

Table 2: Box Behnken experimental design.

Run	Factor X₁	Factor X₂	Factor X₃	Response Y₁	Response Y₂	Response Y₃
1	125	1.25	4	295	64	0.607
2	125	0.25	4	314	77	1.363
3	75	1.25	2	285	74	1.696
4	125	0.75	6	510	69	0.964
5	125	0.75	2	265	82	1.456
6	25	0.25	4	296	75	2.248
7	75	0.25	2	275	74	2.095
8	75	0.25	6	390	79	0.816
9	25	0.75	6	286	72	1.192
10	75	0.75	4	294	71	0.652
11	25	1.25	4	224	59	1.787
12	75	0.75	4	297	74	1.547
13	75	0.75	4	308	73	0.827
14	25	0.75	2	411	69	0.715
15	75	1.25	6	291	55	1.125