Table 5: In-vivo analysis.

Time (h) Percentage drug release Concentration of PTH in lungs (µg/mL) AUC of Pulmonary pharmacokinetic (µgh/mL) Concentration of PTH in blood (µg/mL) AUC of plasma pharmacokinetic (µgh/mL)
PTH nano.a Pure PTH a PTH nano. a Pure PTH a PTH nano. a Pure PTH a PTH nano. a Pure PTH a PTH nano. a Pure PTH a
1 19.77 ± 0.89 38.51 ± 0.59 2.31 ± 0.03 4.56 ± 0.31 15.79±0.20 10.48 ± 2.31 0.09 ± 0.005 0.42 ± 0.03 1.16 ± 0.02 0.728 ± 0.01
2 24.65 ± 0.47 67.62 ± 2.95 2.07 ± 0.01 2.05 ± 0.09 0.096 ± 0.0003 0.14 ± 0.01
3 26.38 ± 1.32 91.41 ± 1.22 2.03 ± 0.01 0.72 ± 0.06 0.079 ± 0.005 0.08 ± 0.01
6 28.67± 0.69 99.84 ± 0.08 0.65 ± 0.04 0.18 ± 0.03 0.074 ± 0.003 0.001 ± 0.001
12 33.02 ± 1.04 --- 0.28 ± 0.03 -- 0.028 ± 0.005 ---
24 40.36 ± 1.47 --- 0.22 ± 0.02 --- 0.025 ± 0.001 ---
a Values are mean ± standard deviation