Fig.(3) Schematic design of the hybrid NP platform. Hybrid NPs are composed of an inorganic or polymeric core (orange) and a polymeric shell (blue). The hybrid NPs host NP agents within their shell and or inside their core. Schematic design showing imaging agent (radio-isotope compound, fluorescent compound) allows the visualization or detection of NPs. The pharmacotherapy agent (active pharmaceutical ingredient) allows drug delivery. The genetic therapy agent (siRNA) allows genetic material delivery. The stealthing agent (PEG, dextran, phospholipids) increases the circulation half-life of nanoparticles. The specific-ligand agent (antibody) allows specific binding to antigen. The specific-targeting agent (HER2, ERBB3, BRAF) allows targeting specific receptors of cancer cells. The functional agent (enzyme) allows biochemical reactions.