The Open Nursing Journal




ISSN: 1874-4346 ― Volume 14, 2020
RESEARCH ARTICLE

Air Quality and Employee Hygiene-related Behavior in a Post Anesthesia Care Unit in Thailand



Somphorn Kampan*
Anesthesia Nursing Unit, Rajavithi Hospital, Bangkok, Thailand

Abstract

Background:

Airborne contaminants in Postanesthesia Care Units (PACUs) such as bacteria, fungi, and waste anesthetic gases pose serious, and sometimes fatal, risks to both patients and PACU workers. Numerous studies have linked long-term exposure to nitrous oxide and halogenated agents to, among other things, reproductive problems in PACU nurses and anesthesiologists. Microorganism contamination can result in a post-surgical complication, to which patients with diabetes and other respiratory diseases are especially vulnerable. Various researchers and governmental agencies have recommended hospitals take steps to reduce levels of airborne contaminants in PACUs. In particular, hazard communication programs are recommended to inform and train staff on relevant occupational health and safety procedures. Additionally, and perhaps more importantly, experts recommend hospitals install specialized ventilation systems to maintain low levels of airborne pollutants.

Objective:

This study has two main parts: (1) measurement of airborne contaminants in the PACU at Rajavithi Hospital in Bangkok, Thailand; and (2) assessment of PACU workers’ perceived level of importance regarding occupational health and safety protocols, via self-reporting survey. The study also has two main objectives: (1) to determine whether, and to what extent, a new ventilation system helps reduce airborne contaminants in the PACU; and (2) to discover whether an informational campaign increases perceived importance of health and safety procedures among PACU workers (i.e. handwashing, changing shoes, wearing proper facemasks).

Methods:

Surveys and air quality measurements were collected two times – in July 2016 and April 2017 – before and after Rajavithi Hospital implemented a hazard communication program consisting of training, posters, brochures, and informational media. Survey participants included all 64 PACU workers – 61 nurses and 3 anesthetists. Air sampling measured levels of bacteria, fungi, nitrous oxide, and desflurane.

Results:

Initial levels of airborne microorganisms were very high (1307CFU/m3 for bacteria and 70.4 CFU/m3 for fungi) and on the high end of normal for nitrous oxide (21.86ppm). Following the informational campaign and installation of the ventilation system, levels of bacterial contamination fell to 182 CFU/m3, and fungi fell to 35.8 CFU/m3. Simultaneously, workers’ levels of perceived importance for health and safety procedures increased.

Conclusion:

Both aspects of the study were successful, however, concentration of airborne microorganisms still exceeded recommended limits at the end of the study. Hospital administration and staff are encouraged to continue training and informing workers while assessing ventilation system until contamination levels fall to within internationally acceptable ranges.

Keywords: PACU, Anesthesiology, OR, Occupational health and safety, Airborne contamination, Air quality.


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 100
Last Page: 107
Publisher Id: TONURSJ-13-100
DOI: 10.2174/1874434601913010100

Article History:

Received Date: 09/08/2018
Revision Received Date: 14/01/2019
Acceptance Date: 07/02/2019
Electronic publication date: 30/04/2019
Collection year: 2019

© 2019 Kampan Somphorn

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Anesthesia Nursing Unit, Rajavithi Hospital, Bangkok, Thailand; Tel: +66 2 354 8108;
E-mail: somphorn2554@hotmail.com






1. INTRODUCTION

In the 1840s, surgeons started using inhalation anesthesia which made it possible for patients to endure extremely painful procedures. Anesthesia use prompted rapid advancements in surgical techniques, but as one problem was solved, another was created. Patients frequently survived invasive procedures in the Operating Room (OR) only to fall victim to a post-anesthesia complication. High rates of post-surgical fatal and non-fatal complications necessitated a special recovery area near the OR. Florence Nightingale was a pioneer in the post-anesthesia care unit concept in the 1860s, but mainstream hospitals did not adopt the units as a part of standard practice until the 1940s [1Cook R. The development of a post anesthesia care unit patient quantitative assessment/predictive tool to manage post-operative health alterations (Unpublished doctoral dissertation).; University of Michigan, Flint, MI, USA.. 2017.2017.].

The European Society of Anesthesiology [2Vimlati L, Gilsanz F, Goldik Z. Quality and safety guidelines of postanaesthesia care. Eur J Anaesthesiol 2009; 26(9): 715-21.
[http://dx.doi.org/10.1097/EJA.0b013e32832bb68f] [PMID: 19390 443]
] defines a Post-Anesthesia Care Unit (PACU) as, “a unit located as close to operating theatres as possible in order to avoid unnecessary time loss for transfer of unstable patients, staffed and equipped for serving for treatment and care of patients during their immediate post anesthesia or post-surgery period, regardless of time of interventions, before they are scheduled to be admitted to general wards, other units of the hospitals or discharged home.” As their utility is well-documented, PACUs are standard facilities in modern hospitals. However, their mere deployment alone does not guarantee a complication-free recovery. As many as 40% of all hospital complications occur in the post-operative environment [1Cook R. The development of a post anesthesia care unit patient quantitative assessment/predictive tool to manage post-operative health alterations (Unpublished doctoral dissertation).; University of Michigan, Flint, MI, USA.. 2017.2017.].

1.1. Risks and Hazards of Contamination

Contamination of a PACU can lead to complications in patients and adverse health consequences among hospital workers. Microorganisms such as bacteria and fungi pose serious threats to patients while long-term exposure to anesthesia gases like nitrous oxide and desflurane present significant risks to the health of nurses and anesthetists. Numerous academic, institutional, and governmental studies have demonstrated types of risks poor air quality can pose in PACUs [2Vimlati L, Gilsanz F, Goldik Z. Quality and safety guidelines of postanaesthesia care. Eur J Anaesthesiol 2009; 26(9): 715-21.
[http://dx.doi.org/10.1097/EJA.0b013e32832bb68f] [PMID: 19390 443]
-4Caggiano G, Napoli C, Coretti C, et al. Mold contamination in a controlled hospital environment: A 3-year surveillance in southern Italy. BMC Infect Dis 2014; 14: 595.http://www.biomedcentral .com/1471-2334/14/595
[http://dx.doi.org/10.1186/s12879-014-0595-z] [PMID: 25398412]
].

Post-anesthesia care presents significant challenges to hospitals and their people as the health and safety of both patients and hospital workers can be at risk if conditions are not properly maintained. The United States’ National Institute for Occupational Safety and Health (NIOSH) [5Waste anesthetic gases: Occupational hazards in hospitals. DHHS (NIOSH) Publication No 2007-151 2007.] and Occupational Safety and Health Administration (OSHA) [62000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html] reported on the potential harms of long-term exposure to anesthesia gases among OR workers. Nitrous oxide (N2O) and halogenated gases may leak from a patient’s breathing circuit or they may be exhaled by patients recovering from anesthesia. NIOSH did not give a conclusive argument that long-term exposure to N2O and halogenated gases like desflurane causes harm, but it made mention of the fact that several studies have linked such exposure to “miscarriages, genetic damage, and concern among operating-room workers”. While OSHA [62000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html] has yet to set permissible limits for N2O and halogenated gases in PACUs, it has provided guidance to other organizations which developed Recommended Exposure Limits (RELs).

1.2. Regulatory Framework

NIOSH issued RELs for N2O - 25ppm - and some halogenated agents - 2ppm [71977.Criteria for a recommended standard: Occupational Exposure to Waste Anesthetic Gases and Vapors. Cincinnati, OH: US Department of Health, Education, and Welfare Public Health Service Center for Disease Control National Institute for Occupational Safety and Health DHEW (NIOSH) Publication No 77-140 ]. Other professional organizations offered N2O RELs of 50ppm. Italy, Sweden, Denmark, and the United Kingdom set N2O RELs of 100ppm [8McGlothlin JD, Moenning JE, Cole SS. Evaluation and control of waste anesthetic gases in the postanesthesia care unit. J Perianesth Nurs 2014; 29(4): 298-312.
[http://dx.doi.org/10.1016/j.jopan.2013.09.010] [PMID: 25062574]
]. OSHA [62000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html] reported acceptable tolerances for halothane at 50ppm, and 75ppm for enflurane. Some relevant publications rely on the 2ppm RELs for all halogenated agents [9Sessler DI, Badgwell JM. Exposure of postoperative nurses to exhaled anesthetic gases. Anesth Analg 1998; 87(5): 1083-8.
[PMID: 9806686]
], including desflurane even though desflurane was introduced long after NIOSH introduced the 2ppm standard [71977.Criteria for a recommended standard: Occupational Exposure to Waste Anesthetic Gases and Vapors. Cincinnati, OH: US Department of Health, Education, and Welfare Public Health Service Center for Disease Control National Institute for Occupational Safety and Health DHEW (NIOSH) Publication No 77-140 ]. NIOSH reported on the need for desflurane specific RELs [102006. NIOSH (2006). Request for information on waste halogenated anesthetic agents: Isoflurane, Desflurane, and Sevoflurane. Cincinnati, OH, USA: NIOSH. Retrieved from https://www.federalregister.gov /documents/2006/02/21/06-1542/request-for-information-on-waste-halogenated-anesthetic-agents-isoflurane-desflurane-and-sevoflurane]. A recent study reported desflurane RELs of 5ppm in Denmark, 10ppm in Sweden and Poland, and 20ppm in Austria [11Aragones J, Ayora A, Ribalta A, et al. Occupational exposure to volatile anesthetics: A systemic review. Occup Med (Chic Ill) 2016; 66: 202-7.
[http://dx.doi.org/10.1093/occmed/kqv193]
]. There is no consensus REL for desflurane, NIOSH has not yet issued RELs for desflurane, and few studies have dealt with desflurane – one of the three halogenated agents most often used today, and the halogenated agent measured in this study at Rajavithi Hospital in Bangkok.

Few governments around the world have offered public guidance on safety limits for bacteria and fungi though studies singularly conclude that such contaminants contribute to postoperative complications, especially in patients with diabetes, weakened immune systems, and respiratory diseases [12Tang CS, Wan GH. Air quality monitoring of the post-operative recovery room and locations surrounding operating theaters in a medical center in Taiwan. PLoS One 2013; 8(4): e61093.
[http://dx.doi.org/10.1371/journal.pone.0061093] [PMID: 23573296]
]. Western Australia Department of Health (WADH) set a limit of 10 bacterial or fungal Colony Forming Units (CFUs) per cubic meter at the patient level [13 Western Australia Department of Health (2015). Microbial air sampling of operating rooms in Western Australian healthcare facilities. Retrieved from http://www.health.wa.gov.au/circular snew/attachments/1055.pdf]. United Kingdom Department of Health (UKDH) recommended bacterial and/or fungal limits of 10CFU/m3 within 300mm of a wound, and 180CFU/m3 for active OR ambient air [14 United Kingdom Department of Health (2007). Heating and ventilation systems. In: Health Technical Memorandum 03-01: Specialised ventilation for healthcare premises. Retrieved from https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/144029/HTM_03-01_Part_A.pdf]. Other countries have set limits of 50—150CFU/m3 for bacteria and fungi [15Anil O. 2008. A research on design of heating and ventilation and air conditioning of hygienic spaces in hospitals (Unpublished master’s thesis). Izmir Institute of Technology, Urla, Turkey. Retrieved from http://library.iyte.edu.tr/tezler/master/makinamuh/T000752.pdf]. One study reported an acceptable threshold of airborne bacterial and/or fungal contamination in a general office environment of 500CFU/m3, which may suffice for the lobby of the hospital but not a PACU [16Luksamijarulkul P, Pipitsangjan S. Microbial air quality and bacterial surface contamination in ambulances during patient services. Oman Med J 2015; 30(2): 104-10.
[http://dx.doi.org/10.5001/omj.2015.23] [PMID: 25960835]
].

The European Agency for Health and Safety at Work (EU-OSHA) mentioned waste anesthetic gases posed a “relatively high” risk to healthcare workers [17 EU-OSHA (2014). Current and emerging issues in the healthcare sector, including home and community care. Luxembourg: Publications Office of the European Union. Retrieved from https://osha.europa.eu/en/tools-and-publications/publications/reports/executive-summary-current-and-emerging-occupational-safety-and-health-osh-issues-in-the-healthcare-sector-including-home-and-community-care]. According to EU-OSHA, communication with employees regarding health and safety issues like waste gas exposure is vital to both employer and employee. An article in the EU-OSHA magazine found inadequate training is the top threat to employee health and safety [18Morsing M. A well thought-out maintenance program increases safety.Healthy workplaces: A European campaign on safe maintenance 2011; 19-21.https://osha.europa.eu/en/tools-and-publications/publications/magazine/magazine12]. The article mentioned that because healthcare institutions often have many, varied, and complex machines, they must frequently develop their own understanding of risks and develop plans of action independently to satisfy their unique needs; employee engagement and feedback are critical to continuing success and improvement.

OSHA regulations grant employees the right to know about chemical hazards in their workplace [19 OSHA (2012). Hazard Communication Standard, 29 CFR 1910.1200. Retrieved from https://www.osha.gov/pls/oshaweb/owadisp.show_ document?p_id=10099&p_table=STANDARDS]. In the United States, employers must also instruct employees on how to protect themselves against those hazards. The State of Minnesota’s OSHA (MN-OSHA) implements federal guidelines in three main parts-identification and labelling of hazardous substances, and employee training. MN-OSHA (2017) requires the hazard communication (HazCom) program to inform employees of hazardous substances; records must be retained; employee training must be frequent and documented [20 MN-OSHA (2017). An employer’s guide to developing a hazard communication or employee right-to-know program. Saint Paul, MN, USA: Minnesota Department of Labor and Industry, Occupational Health and Safety Division. Retrieved from https://www.dli.mn.gov /sites/default/files/pdf/hazcom_ertk_development.pdf]. Similarly, section 32 of Thailand’s Occupational Safety, Health, and Environment Act requires employers to conduct hazard assessments, study potential impacts of the working environment on employees, and prepare plans regarding occupational safety, health, and environment for both employees and supervisors [21Thailand Occupational Safety, Health, and Environment Act, B. E 2011; 2554.].

1.3. Research Aims & Significance

Considering results of historical research, especially publications from governmental organizations [5Waste anesthetic gases: Occupational hazards in hospitals. DHHS (NIOSH) Publication No 2007-151 2007., 62000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html, 13 Western Australia Department of Health (2015). Microbial air sampling of operating rooms in Western Australian healthcare facilities. Retrieved from http://www.health.wa.gov.au/circular snew/attachments/1055.pdf, 14 United Kingdom Department of Health (2007). Heating and ventilation systems. In: Health Technical Memorandum 03-01: Specialised ventilation for healthcare premises. Retrieved from https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/144029/HTM_03-01_Part_A.pdf], Rajavithi undertook the project certain that installation of a new ventilation system would reduce airborne contaminants in the PACU. The research documents change in air quality in the PACU, and in doing so helps the hospital quantify the value of its capital investment. Legal and professional standards compel the hospital to continually make assessments, monitor data, train and retrain staff in attempts to improve the quality of care and safety in the working environment. As part of broader initiatives to improve the hospital, Rajavithi deployed a HazCom and training campaign and sought to estimate its impacts on PACU employees. Once again, hospital staff expected the campaign to produce positive results. The research documents change in PACU staff attitudes toward health and safety procedures, which helps Rajavithi and other healthcare professionals develop continued training and engagement programs as required by law, ethical codes, or professional standards.

Research regarding air quality in PACUs is available but not in abundance. PACUs are specialized niches of hospital systems, and they receive less attention than other domains in healthcare research. Publication concerning PACU standards and practices in Thailand is rare, which lends importance to this study. Research regarding the performance of a HazCom and training program is integral in a healthcare provider’s effort to raise standards in patient care alongside improved occupational health and safety. Thus, stakeholders in Rajavithi Hospital, other hospitals in Thailand, and those around the world may benefit from issues discussed herein and any future studies on related matters.

The utility of the ventilation system is determined by the level to which such systems reduce airborne contaminants (i.e. nitrous oxide, desflurane, bacteria, and fungi). The success of the HazCom and training program is primarily qualified by increases in perceived importance of health and safety behaviors among relevant hospital workers, and secondarily by decreases in airborne contaminants. The researcher assumes that demonstrated improvements in the Rajavithi Hospital PACU suggests that other hospitals in Thailand, and elsewhere, could benefit from implementing either or both ventilation systems and campaigns. Ultimately, positive results in this study could result in saving the lives of patients; better air quality and attentive staff will certainly aid in their recovery and improve working conditions for nurses and anesthetists.

2. METHODS

The research is comprised of two main parts – quantitative measurements of airborne pollutants in the Rajavithi PACU, and self-reporting surveys of PACU workers. Each part has two stages: before and after installation of a ventilation system which occurs during a HazCom and training program. Considering the potentially harmful effects to both patients and hospital workers that atmospheric pollution in the PACU can present, this research first seeks to quantify levels of four separate contaminants – bacteria, fungi, desflurane, and nitrous oxide.

The research then turns to collect survey data to assess the impact of an informational campaign among PACU workers. Two surveys are disseminated-one before launch of the campaign and one following the campaign to quantify PACU workers’ perceived importance of health and safety procedures. Rajavithi administration structured the campaign into broader facilities and service improvement initiatives, including the ventilation system. The time just after installation of the ventilation system was the most convenient for the survey and campaign launch. Survey results confirm or disconfirm the first hypothesis.

2.1. Research Questions and Hypotheses

The first question the research must answer is, “What are the concentrations of bacteria, fungi, desflurane, and nitrous oxide in the Rajavithi Hospital PACU?” Sections 2.2 and 2.4 provide details on the measurement of waste gases and microorganisms. After measuring the levels of atmospheric pollutants, the hospital installs a new ventilation system. Installation immediately following measurement allows the hospital to witness the direct, positive effect of the ventilation system, which provides benefits to patients whose air quality stands to improve.

The second research question is, “Does a HazCom and training program increase PACU worker attention to and concern for health and safety procedures?” The research answers this question with before and after surveys. Sections 2.2 through 2.4 give details of the instrument, participants, and sampling procedure. Following the completion of the informational campaign and second survey, measurements of atmospheric contaminants were taken a second time. Data confirm or disconfirm the first and second hypotheses.

Hypothesis 1: The new ventilation system decreases atmospheric pollution in the PACU.

Hypothesis 2: The hazard communication program increases perceived importance of health and safety procedures among PACU workers.

2.2. Instruments

Rajavithi staff and administration created two simple surveys during the planning stages of the campaign. First, Rajavithi administration surveyed PACU workers, asking if they had experienced various symptoms (e.g. headache, rash, eye irritation) within the year prior. The survey asked participants if they had experienced such symptoms within the past year. “Yes” and “No” were possible answers. A preliminary health survey was administered in June 2016; the follow-up survey was conducted between January and February 2018.

Another survey assessed PACU workers’ attitudes toward health and safety procedures with a 5-point Likert scale where “1” was the lowest level of perceived importance and “5” was the highest. Hospital management administered the perceptions survey in June 2016 and the second April 25-30, 2017.

Waste anesthesia gas in the PACU atmosphere was measured using a TSI Velocicalc Multi-Function Ventilation Meter model 9565-P with a thermoanemometer articulated probe model 966. Atmospheric microorganism contamination was measured using a PBI International air sampler, model Duo SAS Super 360, with dishes for bacteria and fungi detection. The first measurements were taken in July-August 2016 prior to the campaign launch. A second sample was collected April 25-30, 2017.

2.3. Survey Participants

At the time of the study, there were 64 PACU staff members, all of whom were participants. Participation in the survey was mandatory as per employment agreement clauses pertaining to ongoing monitoring, supervision, and training. Participants included 5 males and 59 females, of which there were 61 anesthesia nurses and 3 anesthetists. Mean age of participants was 40. Roughly 60 percent of participants had more than 5 years of experience in their position. No patients were involved in the study.

2.4. Sampling Environment and Procedures

Rajavithi Hospital, in downtown Bangkok, is a 1,200-bed public medical center that can accommodate 40,000 in patients and 1,000,000 out-patients annually [22 Rajavithi Hospital (2018). Hospital profile. Retrieved from http://www.rajavithi.go.th/eng/]. The hospital is staffed by more than 200 doctors, 800 nurses, and more than 4,000 supporting staff. The PACU located adjacent to 22 operating rooms and has an area of 98.02 square meters. Surveys did not request individual respondents to identify themselves. All staff members were able to deposit completed questionnaires discretely and confidentially. No special permission or paperwork was required to collect the data.

Self-reporting surveys always pose a risk of inaccurate or “socially-desirable” reporting, however, any false or misleading response would have violated standards of professional ethics.

An independent outside firm collected air samples and tested for excess anesthetic gas and microorganisms using the instruments listed in section 2.2.

Following initial air sample and survey collections, PACU staff and hospital administration held an exploratory meeting in September 2016, during which time they developed an outline for a hazard communication and training program. The plan consisted of three parts: (1) commissioning a team to inspect the PACU for machine and structural flaws (i.e. broken doors, leaking water pipes, malfunctioning ventilation fans), (2) managing regular inspection of anesthetic equipment (i.e. calibration, leak inspection, joint and junction inspection, etc.), (3) engaging PACU staff with an informational and training campaign.

2.4.1. Ventilation System

During the communication and training program that followed the initial survey, Rajavithi Hospital installed one AirInSpace HEPA Guardian mobile ventilation system. Maximum air flow range of the system is up to 2,500m3/hr. The Guardian system uses H14 and U15 filters.

2.4.2. Communication and Training Campaign

Following the September 2016 open forum meeting among anesthesia nurses, anesthetists, and advisors on sterilization, the hospital initiated a HazCom program to increase the perceived importance of safety and health procedures among PACU workers and to decrease the levels of atmospheric contaminants in the PACU. The campaign commenced in December 2016 and ended in April 2017. The campaign had two main goals: to ensure all anesthesia equipment was effectively monitored and maintained, and to engaged PACU staff with information regarding best practices. A PACU management team was tasked with supervising equipment checks (i.e. calibration, cleaning, and leak inspection). Hospital administration collaborated with PACU senior staff members to engage workers with practical manuals, pamphlets, brochures, and informational media across multiple platforms. The hospital also initiated a PACU worker mentorship program and provided informational sessions with inside and outside experts.

3. RESULTS

Results showed an overall increase in the perceived importance of health and safety procedures among PACU staff and decreased concentration of airborne contaminants in the PACU.

Table 1
Participant responses to question whether they had experienced symptoms in the past year


Table 2
Measured anesthetic gas residue, bacteria and fungi in the PACU during working hours


3.1. Survey Data

In the initial worker health survey, 64 participants reported varying experiences with each of 13 symptoms. More than half of the participants had experienced a headache in the year prior to the survey. In the follow-up survey, the incidence of every symptom had noticeably decreased. Table 1 shows frequencies related to participant health symptoms.

Between the first and second survey, means increased and standard deviations decreased on all survey items. Thus, participants perceived all items to be of higher importance in the second survey compared to the first. Additionally, participants’ responses in the second survey were more uniform than in the first survey. When represented graphically, survey data were grouped more tightly around the high end of the scale in the second set as compared to the first.

3.2. Airborne Pollutants in the PACU

Air samples revealed some contamination in the PACU. Moderate concentrations of N2O were found in both stages of the study. Low concentrations of desflurane were found. Extremely high levels of bacteria were found in the first measurement, a level which fell to just above normal in the second stage. Fungal contaminants were found in moderate amounts. Levels of all four contaminants were lower in the second stage as compared to the first.

4. DISCUSSION

Data collected answered the research question and confirmed both hypotheses.

Initial bacterial concentrations of 1307CFU/m3 exceeded all relevant guidelines the researcher discovered in a review of the literature [23Napoli C, Marcotrigiano V, Montagna MT. Air sampling procedures to evaluate microbial contamination: A comparison between active and passive methods in operating theatres. BMC Public Health 2012; 12: 594.https://dx.doi.org/10.1186%2F1471-2458-12-594
[http://dx.doi.org/10.1186/1471-2458-12-594] [PMID: 22853006]
-25Fekadu S, Getachewu B. Microbial assessment of indoor air of teaching hospital wards: A case of Jimma University Specialized Hospital. Ethiop J Health Sci 2015; 25(2): 117-22.https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4478262/#R22
[http://dx.doi.org/10.4314/ejhs.v25i2.3] [PMID: 26124618]
]. One study considered 500CFU/m3 as the ceiling for a safe hospital waiting room [16Luksamijarulkul P, Pipitsangjan S. Microbial air quality and bacterial surface contamination in ambulances during patient services. Oman Med J 2015; 30(2): 104-10.
[http://dx.doi.org/10.5001/omj.2015.23] [PMID: 25960835]
]. One study found bacterial and fungal pollutants in a Korean hospital lobby in a lower concentration than this study found in the Rajavithi PACU at the beginning of the study [24Park DU, Yeom JK, Lee WJ, Lee KM. Assessment of the levels of airborne bacteria, Gram-negative bacteria, and fungi in hospital lobbies. Int J Environ Res Public Health 2013; 10(2): 541-55.
[http://dx.doi.org/10.3390/ijerph10020541] [PMID: 23435586]
]. Another study considered levels above 1,000CFU/m3 as “contaminated,” which is not a label a hospital desires to have upon its PACU [25Fekadu S, Getachewu B. Microbial assessment of indoor air of teaching hospital wards: A case of Jimma University Specialized Hospital. Ethiop J Health Sci 2015; 25(2): 117-22.https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4478262/#R22
[http://dx.doi.org/10.4314/ejhs.v25i2.3] [PMID: 26124618]
]. Hence, Rajavithi could not wait until after the HazCom and training were complete to install the ventilation system. In the second stage of the study, bacteria levels dropped by 86 percent and fungal count fell by roughly half as compared to initial measurements. Nitrous oxide and desflurane concentrations likewise fell between the first and second stage of measurements. Simultaneously, the perceived importance of health and safety procedure among PACU workers increased between the first and second survey. Additionally, PACU workers reported lower incidence of negative health symptoms following the intervention. Hospital administration inferred the ventilation install and campaign were successful.

Due to presence of an interfering factor (i.e. the ventilation system), it is impossible to determine if increases in the perceived importance of behaviors among staff members directly led reduced contaminants in the PACU atmosphere. The hospital never intended the surveys to quantify a causal relationship; they were intended to show possible effects of the HazCom campaign. Hospital administration and PACU staff had no reason to suspect the ventilation system would not decrease the number of airborne contaminants in the PACU. The coincidental timing of the survey and ventilation system installation did not have an effect on the significance of the study. If the hospital wishes to assess possible relationships between survey items or campaigns and air quality, another survey can be distributed. In fact, ongoing research on employee perceptions of the importance of protocols would likely benefit PACU and hospital staff.

Even though the campaign raised perceived levels of importance of protocols, hospital administration should remain vigilant that every member of the PACU staff always follows those health and safety procedures. Persons reading the results of this research should also remain aware of the limitations of self-reporting surveys, and keep in mind that perception of importance does not necessarily lead to behavior consistent with the item of perceived importance. Microorganism contamination levels in this study were higher than all recommended limits for hygienic spaces in the hospital environment, both before and after the campaign and ventilation installation. Whether these high contamination levels were due to practices among PACU workers, substandard anesthesia scavenging equipment, or still insufficient ventilation is yet unknown. Considering the high level of risk posed by air pollution in PACUs, to both workers and patients, Rajavithi Hospital should continue its efforts to ensure best practices among employees improve air quality through assessment of equipment and ongoing testing of improved ventilation systems.

4.1. Bacteria and Fungi

Ideally, every item on the survey should have received the maximum value for perceived importance. The survey item that received the lowest level of perceived importance in both stages was handwashing - a behavior that can serve to reduce the number of bacteria and fungi transferred from one area to another, both within the PACU and between the PACU and elsewhere in the hospital. Coincidentally, the behavior that participants reported the second lowest perceived importance was wearing a mask when treating a patient - a behavior that can help prevent infection from airborne bacteria or fungi. Handwashing and use of antibacterial gels are essential sanitation and hygiene habits among workers in the hospital generally, and especially in PACUs Table (2). While perceived importance is not an absolute indication of the likelihood that a worker engages in a behavior, hospital administration may consider this point to be the most significant finding in the study. Further reduction of contaminants may be available via more frequent hand sanitation.

Table 3
Perceived importance of health and safety behaviors, before and after campaign


Likewise concerning was the relatively large increase in perceived importance between surveys for items relating to changes of shoes during patient transfer, which suggested workers only became aware of its high importance, or overcame cognitive dissonance, after receiving consistent training and contact with information about the issue. Considering the relatively large increases in perceived importance for several other items on the survey, hospital administrators should investigate this item further.

Overall, the concentration of bacteria fell from a seriously contaminated level to one just above RELs for a hygienic space in the hospital. The researcher inferred that, while worker attitudes probably played a positive role in this reduction, most of this change was due to the installation of the ventilation system. Considering that concentrations at the end of the study were still on the high side, the researcher recommends hospital administration investigate installing additional ventilation while continuing to stress personal hygiene.

4.2. Waste Anesthetic Gases

The item on the survey that showed the greatest increase between stages was regarding wearing the N95 mask when treating patients with respiratory diseases. This result demonstrated PACU workers’ concern for their health relating to potentially contagious diseases, but the lower levels of perceived importance of the other mask item may suggest workers are less concerned about potentially harmful effects of exposure to N2O and desflurane. While N2O levels were below established RELs, workers’ low perceived the importance of facemasks in comparison to other survey items should receive some attention to ensure worker health and safety (Table 3).

Little prior research was found regarding desflurane contamination, and this may be because desflurane is eliminated faster and therefore poses significantly less risk of toxicity due to long-term exposure when compared to older anesthetics like Halothane [26Edwards M. Hazardous post anesthesia care unit (PACU): Reality or myth? A case study (Unpublished master’s thesis). Uniformed Services University of Health Sciences, Bethesda, MD, USA 1999.]. Desflurane is one-eighths as potent as Halothane, one-third as potent as Sevoflurane, and one-fifth as potent as isoflurane [27Eger EI. The clinical use of desflurane. Yale J Biol Med 1993; 66(5): 491-500.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588873/pdf/yjbm00047-0150.pdf
[PMID: 7825350]
]. Desflurane concentrations at Rajavithi Hospital’s PACU were far below general the hospital’s in-house RELs for halogenated agents of 2ppm. One matter of concern for the research was that the hospital also uses sevoflurane in its ORs, but the administration did not approve monitoring and measurement of sevoflurane for the purposes of this study. Thus, even though desflurane levels are very low, it is still possible that hospital staff are exposed to harmful halogenated agents. Bearing that in mind, the researcher recommends Rajavithi Hospital should continue to monitor the PACU atmosphere for the detection and measurement of all anesthetic gases in use at the hospital, every six months as recommended by OSHA [62000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html].

4.3. Continued Monitoring and Measurement at Rajavithi Hospital

Hospital administrators were, and should be, pleased to witness declines in airborne pollutants in the hospitals’ post anesthesia care unit. The campaign was an apparent success, especially with regards to bacteria, but the success was limited given that N2O levels were within 20 percent of RELs while bacterial and fungal concentrations still exceeded several sources’ RELs at the end of the study. The positive results of the study demonstrate that contaminations levels can be significantly reduced over the course of months with the addition of a ventilation system, and by making efforts to ensure all personnel involved remain conscious of the importance of health and safety procedures. Like all surgical hospitals, Rajavithi should continue to monitor and measure air quality in the PACU, troubleshoot potential impediments to further reduction of pollutants, and devise new solutions such that air quality is maintained well under RELs for all gases and particulate matter.

A main concern for hospital administration presently is to continue monitoring, and to do so frequently, so they can avoid making hasty or unwarranted conclusions about the effectiveness of the ventilation system and information campaign. One aspect of the study that may have been overlooked is that levels of airborne bacteria and fungi are naturally affected by seasonal changes [28Aydogdu H, Asan A, Otkun M, Ture M. Monitoring of fungi and bacteria in the indoor air o primary schools in Edirine City, Turkey. Indoor Built Environ 2005; 14: 411-25.https://doi.org/10.1177 %2F1420326X05057539
[http://dx.doi.org/10.1177/1420326X05057539]
-30Chaivisit P, Fontana A, Galindo S, et al. Airborne bacteria and fungi distribution characteristics in natural ventilation system of a university hospital in Thailand. Environ Asia 2018; 11(2): 53-66.
[http://dx.doi.org/10.14456/ea.2018.22]
]. Rajavithi administration should consider the possibility that the lower bacteria and fungi count in the second sample was due in part to ambient temperature and humidity. Notwithstanding the possibility that some of the variation was due to weather, research at Thai hospitals previously found that occupant number is the primary source of airborne bacteria and fungi [30Chaivisit P, Fontana A, Galindo S, et al. Airborne bacteria and fungi distribution characteristics in natural ventilation system of a university hospital in Thailand. Environ Asia 2018; 11(2): 53-66.
[http://dx.doi.org/10.14456/ea.2018.22]
].

The single most important finding of this study was that microorganism contamination levels were higher than all recommended limits for hygienic spaces in a hospital environment. Whether these high contamination levels were due to practices among PACU workers, overcrowding in the hospital, substandard anesthesia scavenging equipment, or insufficient ventilation is yet unknown. Considering the high level of risk posed by air pollution in PACUs, to both workers and patients, Rajavithi Hospital should continue to assess equipment and ventilation systems. Hospital administration and donors may need to make room in the budget for new and improved gas scavenging and ventilation equipment.

4.4. Broader Implications of the Study

Air quality is an issue of importance in all hospitals; and given that Rajavithi Hospital successfully implemented technology and an informational program which led to reduction in airborne pollutants in a hygienic zone, this research can be helpful to other hospitals in Thailand and elsewhere around the world. OSHA [62000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html] has promoted HEPA ventilation systems and HazCom programs for years, so the concepts are nothing new; but, by demonstrating their effectiveness in Thailand through this study, Thai hospital workers should be persuaded. Given that Rajavithi is a government hospital, the results of this study can easily be transmitted through the Ministry of Health to hundreds of other public hospitals. Dissemination of findings, in combination with continued research and monitoring, should further promote the issue of PACU hygiene and thereby improve recovery of patients, health and safety conditions for all persons in the PACU.

CONCLUSION

This study measured the air quality in Rajavithi’s PACU in July 2016 and found concentrations of microorganisms, especially bacteria, were alarmingly high. Through installation of a ventilation system and implementation of a hazard awareness program, the hospital drastically reduced the concentration of airborne contaminants by March 2017. During the same period, an informational campaign aimed to increase employee awareness of safety protocols was undertaken. Two survey questionnaires showed PACU workers’ attitudes toward health and safety procedures improved over the course of the campaign. While the findings cannot determine the exact extent to which the ventilation system or informational campaign led to reduction in PACU airborne contaminants, the overall result suggests both were successful.

This project led to recommendations for Rajavithi Hospital. Firstly, the hospital should continue training and informing its PACU and other workers on the importance of all health and safety procedures. A compliance office may be of assistance in ensuring best practices. Secondly, the hospital should continue monitoring and measuring its air quality in the PACU, including testing for all anesthetic gases, and with the aim of identifying the specific strands of bacteria and fungi present. Also, the hospital should adjust the current ventilation system such that concentrations of pollutants fall within RELs, or the hospital should improve the ventilation system through additional purchases or remodeling of the PACU. Finally, the hospital should partner with officials from Ministry of Health and other hospitals to spearhead a campaign designed to help other hospitals in the Thai health system achieve proper hygiene in their PACU environments. Through continued research, monitoring, communication, and investment, both patients and hospital workers can avoid unnecessary complications and unfortunate consequences.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

Not applicable.

HUMAN AND ANIMAL RIGHTS

No animals/humans were used for studies that are the basis of this research.

CONSENT FOR PUBLICATION

Not applicable.

AVAILABILITY OF DATA AND MATERIAL

The data supporting the findings of the article is available in the author's Google Drive at https://drive.google.com/drive/ folders/19X9u-ZCbCXLLJswOk_VMk80gdD-RU80_?usp =sharing, reference number 1.

FUNDING

None.

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENTS

The researcher expresses gratitude to Adam Tanielian for assistance in the editing and preparation of this manuscript.

SUPPLEMENTARY MATERIAL

Supplementary material is available on the publishers Website along with the published article.

Download File


REFERENCES

[1] Cook R. The development of a post anesthesia care unit patient quantitative assessment/predictive tool to manage post-operative health alterations (Unpublished doctoral dissertation).; University of Michigan, Flint, MI, USA.. 2017.2017.
[2] Vimlati L, Gilsanz F, Goldik Z. Quality and safety guidelines of postanaesthesia care. Eur J Anaesthesiol 2009; 26(9): 715-21.
[http://dx.doi.org/10.1097/EJA.0b013e32832bb68f] [PMID: 19390 443]
[3] McGregor DG, Senjem DH, Mazze RI. Trace nitrous oxide levels in the postanesthesia care unit. Anesth Analg 1999; 89(2): 472-5.
[PMID: 10439769]
[4] Caggiano G, Napoli C, Coretti C, et al. Mold contamination in a controlled hospital environment: A 3-year surveillance in southern Italy. BMC Infect Dis 2014; 14: 595.http://www.biomedcentral .com/1471-2334/14/595
[http://dx.doi.org/10.1186/s12879-014-0595-z] [PMID: 25398412]
[5] Waste anesthetic gases: Occupational hazards in hospitals. DHHS (NIOSH) Publication No 2007-151 2007.
[6] 2000. OSHA (2000). Anesthetic gases: Guidelines for workplace exposures. Retrieved from https://www.osha.gov/dts/osta/anesth eticgases/index.html
[7] 1977.Criteria for a recommended standard: Occupational Exposure to Waste Anesthetic Gases and Vapors. Cincinnati, OH: US Department of Health, Education, and Welfare Public Health Service Center for Disease Control National Institute for Occupational Safety and Health DHEW (NIOSH) Publication No 77-140
[8] McGlothlin JD, Moenning JE, Cole SS. Evaluation and control of waste anesthetic gases in the postanesthesia care unit. J Perianesth Nurs 2014; 29(4): 298-312.
[http://dx.doi.org/10.1016/j.jopan.2013.09.010] [PMID: 25062574]
[9] Sessler DI, Badgwell JM. Exposure of postoperative nurses to exhaled anesthetic gases. Anesth Analg 1998; 87(5): 1083-8.
[PMID: 9806686]
[10] 2006. NIOSH (2006). Request for information on waste halogenated anesthetic agents: Isoflurane, Desflurane, and Sevoflurane. Cincinnati, OH, USA: NIOSH. Retrieved from https://www.federalregister.gov /documents/2006/02/21/06-1542/request-for-information-on-waste-halogenated-anesthetic-agents-isoflurane-desflurane-and-sevoflurane
[11] Aragones J, Ayora A, Ribalta A, et al. Occupational exposure to volatile anesthetics: A systemic review. Occup Med (Chic Ill) 2016; 66: 202-7.
[http://dx.doi.org/10.1093/occmed/kqv193]
[12] Tang CS, Wan GH. Air quality monitoring of the post-operative recovery room and locations surrounding operating theaters in a medical center in Taiwan. PLoS One 2013; 8(4): e61093.
[http://dx.doi.org/10.1371/journal.pone.0061093] [PMID: 23573296]
[13] Western Australia Department of Health (2015). Microbial air sampling of operating rooms in Western Australian healthcare facilities. Retrieved from http://www.health.wa.gov.au/circular snew/attachments/1055.pdf
[14] United Kingdom Department of Health (2007). Heating and ventilation systems. In: Health Technical Memorandum 03-01: Specialised ventilation for healthcare premises. Retrieved from https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/144029/HTM_03-01_Part_A.pdf
[15] Anil O. 2008. A research on design of heating and ventilation and air conditioning of hygienic spaces in hospitals (Unpublished master’s thesis). Izmir Institute of Technology, Urla, Turkey. Retrieved from http://library.iyte.edu.tr/tezler/master/makinamuh/T000752.pdf
[16] Luksamijarulkul P, Pipitsangjan S. Microbial air quality and bacterial surface contamination in ambulances during patient services. Oman Med J 2015; 30(2): 104-10.
[http://dx.doi.org/10.5001/omj.2015.23] [PMID: 25960835]
[17] EU-OSHA (2014). Current and emerging issues in the healthcare sector, including home and community care. Luxembourg: Publications Office of the European Union. Retrieved from https://osha.europa.eu/en/tools-and-publications/publications/reports/executive-summary-current-and-emerging-occupational-safety-and-health-osh-issues-in-the-healthcare-sector-including-home-and-community-care
[18] Morsing M. A well thought-out maintenance program increases safety.Healthy workplaces: A European campaign on safe maintenance 2011; 19-21.https://osha.europa.eu/en/tools-and-publications/publications/magazine/magazine12
[19] OSHA (2012). Hazard Communication Standard, 29 CFR 1910.1200. Retrieved from https://www.osha.gov/pls/oshaweb/owadisp.show_ document?p_id=10099&p_table=STANDARDS
[20] MN-OSHA (2017). An employer’s guide to developing a hazard communication or employee right-to-know program. Saint Paul, MN, USA: Minnesota Department of Labor and Industry, Occupational Health and Safety Division. Retrieved from https://www.dli.mn.gov /sites/default/files/pdf/hazcom_ertk_development.pdf
[21] Thailand Occupational Safety, Health, and Environment Act, B. E 2011; 2554.
[22] Rajavithi Hospital (2018). Hospital profile. Retrieved from http://www.rajavithi.go.th/eng/
[23] Napoli C, Marcotrigiano V, Montagna MT. Air sampling procedures to evaluate microbial contamination: A comparison between active and passive methods in operating theatres. BMC Public Health 2012; 12: 594.https://dx.doi.org/10.1186%2F1471-2458-12-594
[http://dx.doi.org/10.1186/1471-2458-12-594] [PMID: 22853006]
[24] Park DU, Yeom JK, Lee WJ, Lee KM. Assessment of the levels of airborne bacteria, Gram-negative bacteria, and fungi in hospital lobbies. Int J Environ Res Public Health 2013; 10(2): 541-55.
[http://dx.doi.org/10.3390/ijerph10020541] [PMID: 23435586]
[25] Fekadu S, Getachewu B. Microbial assessment of indoor air of teaching hospital wards: A case of Jimma University Specialized Hospital. Ethiop J Health Sci 2015; 25(2): 117-22.https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4478262/#R22
[http://dx.doi.org/10.4314/ejhs.v25i2.3] [PMID: 26124618]
[26] Edwards M. Hazardous post anesthesia care unit (PACU): Reality or myth? A case study (Unpublished master’s thesis). Uniformed Services University of Health Sciences, Bethesda, MD, USA 1999.
[27] Eger EI. The clinical use of desflurane. Yale J Biol Med 1993; 66(5): 491-500.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588873/pdf/yjbm00047-0150.pdf
[PMID: 7825350]
[28] Aydogdu H, Asan A, Otkun M, Ture M. Monitoring of fungi and bacteria in the indoor air o primary schools in Edirine City, Turkey. Indoor Built Environ 2005; 14: 411-25.https://doi.org/10.1177 %2F1420326X05057539
[http://dx.doi.org/10.1177/1420326X05057539]
[29] Frankel M, Bekö G, Timm M, Gustavsen S, Hansen EW, Madsen AM. Seasonal variations of indoor microbial exposures and their relation to temperature, relative humidity, and air exchange rate. Appl Environ Microbiol 2012; 78(23): 8289-97.https://dx.doi.org/10.1128% 2FAEM.02069-12
[http://dx.doi.org/10.1128/AEM.02069-12] [PMID: 23001651]
[30] Chaivisit P, Fontana A, Galindo S, et al. Airborne bacteria and fungi distribution characteristics in natural ventilation system of a university hospital in Thailand. Environ Asia 2018; 11(2): 53-66.
[http://dx.doi.org/10.14456/ea.2018.22]

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